Evidence map›Paper›PMID 33554609›Full record

Observational studyCirculation. Arrhythmia and electrophysiology2021

Metformin Is Associated With a Lower Risk of Atrial Fibrillation and Ventricular Arrhythmias Compared With Sulfonylureas: An Observational Study.

Anna Ostropolets, Pierre A Elias, Michael V Reyes, Elain Y Wan, Utpal B Pajvani, George Hripcsak, John P Morrow

Registry-linked trialOpen access · bronzeAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation. Arrhythmia and electrophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05878535 (The Efficacy And Safety Of Metformin For The Treatment Of Atrial Fibrillation), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05878535 phase2unknown statusnot on this mapstarted 2024, after this paper: background citation

The Efficacy And Safety Of Metformin For The Treatment Of Atrial Fibrillation

TypeinterventionalSponsorArab Contractors Medical CentreRan2024 to 2025Enrolled770ConditionsAtrial FibrillationArmsMetformin, Placebo
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
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  7. Metformin Protects Against Persistent Atrial Fibrillation in an Equine Model.Circulation. Arrhythmia and electrophysiology · 2025
    Article
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  12. Upstream targeting for the prevention of atrial fibrillation: Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF)-rationale and study design.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Anna OstropoletsDepartment of Biomedical Informatics (A.O., G.H.), College of Physicians and Surgeons of Columbia University, NY.
Pierre A EliasDepartment of Medicine (P.A.E., M.V.R., E.Y.W., U.B.P., G.H., J.P.M.), College of Physicians and Surgeons of Columbia University, NY.
Michael V ReyesDepartment of Medicine (P.A.E., M.V.R., E.Y.W., U.B.P., G.H., J.P.M.), College of Physicians and Surgeons of Columbia University, NY.
Elain Y WanDepartment of Medicine (P.A.E., M.V.R., E.Y.W., U.B.P., G.H., J.P.M.), College of Physicians and Surgeons of Columbia University, NY.
Utpal B PajvaniDepartment of Medicine (P.A.E., M.V.R., E.Y.W., U.B.P., G.H., J.P.M.), College of Physicians and Surgeons of Columbia University, NY.
George HripcsakDepartment of Biomedical Informatics (A.O., G.H.), College of Physicians and Surgeons of Columbia University, NY.
John P MorrowDepartment of Medicine (P.A.E., M.V.R., E.Y.W., U.B.P., G.H., J.P.M.), College of Physicians and Surgeons of Columbia University, NY.
Columbia University · USColumbia College · CA

Funding

DISCOVERING AND APPLYING KNOWLEDGE IN CLINICAL DATABASESR01LM006910 · NLM · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HRIPCSAK, GEORGE M · 2000 to 2023
$10.6M
Molecular mechanisms of arrhythmia caused by high-fat dietR01HL136758 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MORROW, JOHN PEARCE · 2018 to 2022
$2.0M
NHLBI NIH HHS R01 HL136758NLM NIH HHS R01 LM006910
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Administration, OralAtrial FibrillationDatabases, FactualDiabetes Mellitus, Type 2Drug Therapy, CombinationHumansHypoglycemic AgentsMetforminRetrospective StudiesRisk AssessmentRisk FactorsSulfonylurea CompoundsTachycardia, VentricularTime FactorsTreatment OutcomeVentricular FibrillationHypoglycemic AgentsMetforminSulfonylurea Compoundsatrial fibrillationmetforminpropensity scorethiazolidinedionesventricular fibrillation

Identifiers

PMID33554609
PMCPMC7969445
OpenAlexW3128709333

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.