Evidence map›Paper›PMID 33554422›Full record

ArticleStem cells (Dayton, Ohio)2021

Urine stem cells are equipped to provide B cell survival signals.

Asmaa A Zidan, Griffith B Perkins, Mohammed Al-Hawwas, Ahmed Elhossiny, Jianyu Yang, Larisa Bobrovskaya, Ghada M Mourad, Xin-Fu Zhou, Plinio R Hurtado

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells (Dayton, Ohio), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Advances in Stem Cell Immunotherapy.Stem cells (Dayton, Ohio) · 2023
    Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Asmaa A ZidanHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0001-8248-8190
Griffith B PerkinsDepartment of Molecular & Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Mohammed Al-HawwasHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Ahmed ElhossinyDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Jianyu YangHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Larisa BobrovskayaHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Ghada M MouradDepartment of Medical Histology and Cell Biology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Xin-Fu ZhouHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Plinio R HurtadoDepartment of Renal Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID 0000-0002-0913-7797
University of South Australia · AUAlexandria University · EGRoyal Adelaide Hospital · AUThe University of Adelaide · AUUniversity of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interplay between mesenchymal stem cells (MSCs) and immune cells has been studied for MSCs isolated from different tissues. However, the immunomodulatory capacity of urine stem cells (USCs) has not been adequately researched. The present study reports on the effect of USCs on peripheral blood lymphocytes. USCs were isolated and characterized before coculture with resting and with anti-CD3/CD28 bead stimulated lymphocytes. Similarly to bone marrow mesenchymal stem cells (BM-MSCs), USCs inhibited the proliferation of activated T lymphocytes and induced their apoptosis. However, they also induced strong activation, proliferation, and cytokine and antibody production by B lymphocytes. Molecular phenotype and supernatant analysis revealed that USCs secrete a range of cytokines and effector molecules, known to play a central role in B cell biology. These included B cell-activating factor (BAFF), interleukin 6 (IL-6) and CD40L. These findings raise the possibility of an unrecognized active role for kidney stem cells in modulating local immune cells.

Indexed as

B-LymphocytesBone Marrow CellsCell ProliferationCell SurvivalCoculture TechniquesCytokinesHumansLymphocyte ActivationMesenchymal Stem CellsStem CellsT-LymphocytesCytokinesBAFFB cellscytokinesmesenchymal stem cellsT cellsurine stem cells

Identifiers

PMID33554422
PMCPMC8248326
OpenAlexW3126378015

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.