ArticleBiochemical genetics2021
Identification and Transcriptional Analysis of Zinc Finger-Homeodomain (ZF-HD) Family Genes in Cucumber.
Article in Biochemical genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Genomics assisted breeding for mildew resistance in cucumber: from gene discovery to future innovations.Plant molecular biology · 2026Review
- Genome-Wide Analysis of Callose Synthase (CALS) Genes in Cabbage (International journal of molecular sciences · 2025Article
- Genome-wide association study reveals putative candidate genes in cucumber (Cucumis sativus L.) associated with shoot and root system architecture traits under water stress conditions.BMC plant biology · 2025Article
- Genome-wide identification and expression analysis of ZF-HD family in sunflower (Helianthus annuus L.) under drought and salt stresses.BMC plant biology · 2025Article
- ZF-HD gene family in rapeseed (Brassica napus L.): genome-wide identification, phylogeny, evolutionary expansion and expression analyses.BMC genomics · 2024Article
- Genetic Insights and Molecular Breeding Approaches for Downy Mildew Resistance in Cucumber (International journal of molecular sciences · 2024Review
- Systematic Analysis of Zinc Finger-Homeodomain Transcription Factors (ZF-HDs) in Barley (Genes · 2024Article
- Genome-Wide Identification and Analysis ofPlants (Basel, Switzerland) · 2023Article
- In silico and computational analysis of zinc finger motif-associated homeodomain (ZF-HD) family genes in chilli (Capsicum annuum L).BMC genomics · 2023Article
- Genome-Wide Identification and In Silico Analysis of ZF-HD Transcription Factor Genes inGenes · 2022Article
- Serial-Omics and Molecular Function Study Provide Novel Insight into Cucumber Variety Improvement.Plants (Basel, Switzerland) · 2022Review
- Research Advances in Genetic Mechanisms of Major Cucumber Diseases Resistance.Frontiers in plant science · 2022Review
- Genome-wide identification and expression analysis of the ZF-HD gene family in pea (Frontiers in genetics · 2022Article
- Genome-Wide Analysis of the Homeobox Gene Family and Identification of Drought-Responsive Members inPlants (Basel, Switzerland) · 2021Article
- Genome-Wide Investigation of the Zinc Finger-Homeodomain Family Genes Reveals Potential Roles in Apple Fruit Ripening.Frontiers in genetics · 2021Article
- Functional characterization ofPeerJ · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Zinc finger-homeodomain (ZF-HD) proteins encode a family of plant-specific transcription factors that play essential roles in regulating plant growth and development as well as responses to abiotic/biotic stresses by activating or repressing the target genes. In this study, genome-wide characterization and expression profiling of the ZF-HD gene family in cucumber (Cucumis sativus) were performed for the first time. By using bioinformatics approaches, a total of 13 ZF-HD genes (designated as CsMIF1-CsMIF3 and CsZHD1-CsZHD10) were identified in the cucumber genome, which were unevenly distributed on six chromosomes. According to the phylogenetic analysis of cucumber and other species, they were divided into two distinct families, MINI ZINC FINGER (MIF) and zinc finger-homeodomain (ZHD), and the ZHD family was further divided into six subfamilies (ZHDI-ZHDVI). CsZF-HD members were mostly conserved in each subfamily with minor variations in motif distribution, and gene structure analysis showed that the CsZF-HD genes had only one intron or no intron at all. Expression analysis showed that most CsZF-HD genes had tissue-specific expression patterns, and some of them exhibited highly variable expression during fruit development. qRT-PCR results indicated that the selected CsZF-HD genes were responsive to drought stress, and some of them were differentially expressed in response to the inoculation of powdery mildew (PM) and downy mildew (DM) based on publicly available RNA-seq data. The results lay the foundation for further functional analysis of the ZF-HD genes and explore their potential application to the improvement of stress tolerance in cucumber.
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