Evidence map›Paper›PMID 33554318›Full record

ReviewCardiovascular toxicology2021

Parenteral Nutrition and Cardiotoxicity.

Johan van Nispen, Marcus Voigt, Eric Song, Austin Armstrong, Margarita Fedorova, Vidul Murali, Joseph Krebs, Ashish Samaddar, Chandrashekhara Manithody, Ajay Jain

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cardiovascular toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Johan van NispenDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA. Johan.vannispen@health.slu.edu.ORCID http://orcid.org/0000-0002-4157-118X
Marcus VoigtDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA.
Eric SongDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA.
Austin ArmstrongDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA.
Margarita FedorovaDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA.
Vidul MuraliDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA.
Joseph KrebsDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA.
Ashish SamaddarDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA.
Chandrashekhara ManithodyDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA.
Ajay JainDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA.
Saint Louis University · USSaint Louis University · ES

Funding

Role of the bile acid activated receptors FXR and TGR5 in Total Parenteral Nutrition associated hepatic and gut diseaseK08DK098623 · NIDDK · SAINT LOUIS UNIVERSITY · PI JAIN, AJAY K. · 2016 to 2021
$821k
Role of intestinal microbiota in driving injury mechanisms in short bowel syndromeR21AI169487 · NIAID · SAINT LOUIS UNIVERSITY · PI JAIN, AJAY K. · 2022 to 2023
$428k
Enhancing Health Care Access with Cellular TechnologyR03EB015955 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2015 to 2016
$256k
NIAID NIH HHS R21 AI169487NIBIB NIH HHS R03 EB015955NIDDK NIH HHS K08 DK098623
6 · The paper itself

Abstract

Parenteral nutrition (PN) is a life-saving nutritional therapy for those situations when patients are unable to receive enteral nutrition. However, despite a multitude of benefits offered by PN, it is associated with a variety of side effects, most notably parenteral nutrition-associated liver disease (PNALD). Adverse effects of PN on other organ systems, such as brain and cardiovascular system, have been poorly studied. There have been several case reports, studies, and a recent animal study highlighting cardiotoxic effects of PN; however, much remains unclear about the underlying mechanisms causing cardiac damage. In this review, we propose a series of potential mechanisms behind PN-associated heart injury, and we provide an overview of therapeutic strategies and recent scientific advances.

Indexed as

Oxidative StressAnimalsAntioxidantsBiopterinsCardiotoxicityHeart DiseasesHumansParenteral NutritionReactive Oxygen SpeciesReceptors, G-Protein-CoupledSignal TransductionAntioxidantsBiopterinsGPBAR1 protein, humanReactive Oxygen SpeciesReceptors, G-Protein-CoupledsapropterinEndothelial nitric oxide synthaseParenteral nutritionReactive oxygen speciesTetrahydrobiopterin

Identifiers

PMID33554318
OpenAlexW3128714063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.