Evidence map›Paper›PMID 33554153›Full record

ArticleJVS-vascular science2020

Canonical transient receptor potential 6 channel deficiency promotes smooth muscle cells dedifferentiation and increased proliferation after arterial injury.

Andrew H Smith, Priya Putta, Erin C Driscoll, Pinaki Chaudhuri, Lutz Birnbaumer, Michael A Rosenbaum, Linda M Graham

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JVS-vascular science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. TRPC6-Mediated ZnBiomolecules · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Andrew H SmithDepartment of Vascular Surgery, Cleveland Clinic, Cleveland.
Priya PuttaDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland.
Erin C DriscollDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland.
Pinaki ChaudhuriDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland.
Lutz BirnbaumerNeurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park.
Michael A RosenbaumDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland.
Linda M GrahamDepartment of Vascular Surgery, Cleveland Clinic, Cleveland.
Cleveland Clinic · USPontificia Universidad Católica Argentina · AR

Funding

EFFECT OF LIPIDS ON VASCULAR GRAFT HEALINGR01HL064357 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI GRAHAM, LINDA M · 2000 to 2021
$7.0M
Transmembrane Signaling Mechanisms Involving TRP ChannelsZ01ES101684 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$2.1M
Effect of Lipids on Vascular Graft HealingR56HL064357 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI GRAHAM, LINDA M · 2009 to 2009
$465k
Endothelial Healing is Inhibited by PI3 Kinase-Induced Activation of TRPC6IK2BX003628 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI ROSENBAUM, MICHAEL AARIC · 2017 to 2021
–
BLRD VA IK2 BX003628Intramural NIH HHS Z01 ES101684NHLBI NIH HHS R01 HL064357NHLBI NIH HHS R56 HL064357
6 · The paper itself

Abstract

objectivePrevious studies showed the benefit of canonical transient receptor potential 6 (TRPC6) channel deficiency in promoting endothelial healing of arterial injuries in hypercholesterolemic animals. Long-term studies utilizing a carotid wire-injury model were undertaken in wild-type (WT) and TRPC6

methodsThe common carotid arteries (CCA) of WT and TRPC6

conclusionsThese results suggest that TRPC6 contributes to the restoration or maintenance of arterial SMC contractile phenotype following injury. Understanding the role of TRPC6 in phenotypic modulation may lead to mechanism-based therapies for attenuation of IH.

Indexed as

Carotid injuryIntimal hyperplasiaPhenotypic modulationSmooth muscle cellsTRPC6

Identifiers

PMID33554153
PMCPMC7861475
OpenAlexW3045230676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.