ArticleEClinicalMedicine2021
Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins.
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- [A real-world study on the association between treatment of patent ductus arteriosus in extremely preterm infants and the risk of bronchopulmonary dysplasia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- The impact of antenatal corticosteroids on respiratory and metabolic outcomes in late-preterm births depends on timing, number of courses, and singleton/twin status: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Research progress on biomarkers associated with neonatal respiratory distress syndrome.Frontiers in pediatrics · 2026Review
- In vivo and ex vivo cardiovascular haemodynamic responses of preterm growth-restricted lambs to perinatal asphyxia.Clinical science (London, England : 1979) · 2025Article
- Compromised cardiopulmonary transition in fetal growth restricted and small for gestational age neonates.The Journal of physiology · 2025Review
- Clinical guidance VVOG: Antenatal care for twin pregnancies.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- The Impact of Thrombophilia on Maternal and Neonatal Outcomes: A Multisystem Analysis of Clinical, Hematological, and Metabolic Parameters.Journal of clinical medicine · 2025Article
- Increased Risk of Persistent Pulmonary Hypertension of the Newborn in Twin Anaemia Polycythaemia Sequence Donors.Fetal diagnosis and therapy · 2025Article
- Enhancing the Retinopathy Of Prematurity Risk Profile Through Placental Evaluation of Maternal and Fetal Vascular Malperfusion.Investigative ophthalmology & visual science · 2024Article
- Role of Myeloperoxidase, Oxidative Stress, and Inflammation in Bronchopulmonary Dysplasia.Antioxidants (Basel, Switzerland) · 2024Review
- [Risk factors for bronchopulmonary dysplasia in twin preterm infants: a multicenter study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Reduced lung function during childhood in identical twins with discordant fetal growth: a cohort study.EClinicalMedicine · 2024Article
- Nutrition and Growth of Preterm Neonates during Hospitalization: Impact on Childhood Outcomes.Nutrients · 2024Article
- Descriptive and Functional Genomics in Neonatal Respiratory Distress Syndrome: From Lung Development to Targeted Therapies.International journal of molecular sciences · 2024Review
- Establishing Reference Intervals for Normal Fetal Lung Biological Parameters at 21-40 Weeks of Gestation in the Chinese Population: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2023Article
- Association between fetal growth-restriction and retinopathy of prematurity using a unique identical twin model.Pediatric research · 2023Article
- Extrauterine Growth Restriction and Optimal Growth of Very Preterm Neonates: State of the Art.Nutrients · 2023Article
- Artificial Intelligence-Driven Respiratory Distress Syndrome Prediction for Very Low Birth Weight Infants: Korean Multicenter Prospective Cohort Study.Journal of medical Internet research · 2023Article
- Bronchopulmonary Dysplasia: Pathogenesis and Pathophysiology.Journal of clinical medicine · 2023Review
- Appropriate Delivery Timing in Fetuses with Fetal Growth Restriction to Reduce Neonatal Complications: A Case-Control Study in Romania.Journal of personalized medicine · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFetal growth restriction (FGR) is thought to negatively affect lung development resulting in increased respiratory morbidity. However, research performed in singletons is often limited by a certain level of bias caused by individual differences in genetic constitution, obstetrical and maternal factors.
methodsRespiratory morbidity was compared between the smaller and the larger twin in monochorionic twins with selective fetal growth restriction (sFGR), defined as a birth weight discordance ≥ 20%, born in our center between 2010 and 2019 in this retrospective study. Respiratory distress syndrome (RDS) was diagnosed based on the clinical picture of a neonate with respiratory failure requiring mechanical ventilation and/or surfactant, confirmed by a chest X-ray. Bronchopulmonary dysplasia (BPD) was diagnosed when the neonate required treatment with >21% oxygen for at least 28 days.
findingsMedian gestational age at birth for the 94 included pregnancies was 32.4 (IQR 30.4-34.3) weeks. Within-pair analyses showed that the prevalence of RDS was lower in the smaller twin compared to the larger twin, 19.1% (18/94) vs 34.0% (32/94), respectively (
interpretationDespite being genetically identical, sFGR twins have different respiratory outcomes. Adverse growth condition
fundingThe Dutch Heart Foundation (2017T075).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.