ArticleEClinicalMedicine2021
Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA).
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A metabolomic clock of population ageing: cross-cohort validation and associations with frailty and cognitive function.GeroScience · 2026Article
- Associations of leisure-time physical activity with muscle strength and functional fitness domains among community-dwelling older adults: a cross-sectional study.BMC geriatrics · 2026Article
- Autistic Trait Level and Reaction Time in Older Adults: The Influence of Sex and Task upon Study Outcome.Autism in adulthood · 2026Article
- Gender- and domain-specific effects of a 6-month multidimensional exercise program on attention and verbal fluency in physically inactive older adults.Frontiers in aging · 2026Article
- The relationship between cognitive function and quality of life in older hypertension patients: a parallel mediation effect of frailty and medication discrepancies.BMC geriatrics · 2025Article
- The association between mobility and a cognitive measure of attention and processing speed in middle-aged adults: a cross-sectional study.Scientific reports · 2025Article
- Longitudinal Study on Sustained Attention to Response Task (SART): Clustering Approach for Mobility and Cognitive Decline.Geriatrics (Basel, Switzerland) · 2022Article
- SART and Individual Trial Mistake Thresholds: Predictive Model for Mobility Decline.Geriatrics (Basel, Switzerland) · 2021Article
- Comparison of Gait Speed Reserve, Usual Gait Speed, and Maximum Gait Speed of Adults Aged 50+ in Ireland Using Explainable Machine Learning.Frontiers in network physiology · 2021Article
- Predicting Age From Behavioral Test Performance for Screening Early Onset of Cognitive Decline.Frontiers in aging neuroscience · 2021Article
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Authors and funding
2 authors.
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Abstract
backgroundCognitive and motor function in ageing are intertwined, but whether slower motor response time (MRT) to a cognitive stimulus could herald accelerated mobility decline is unknown. Using data from The Irish Longitudinal Study on Ageing (TILDA), we examined whether slower MRT may predict a greater than expected increase in Time Up and Go (TUG) after 4 years.
methodsParticipants aged 50 years or older were divided into two groups based on their mean MRT (< 250 ms versus ≥ 250 ms). A repeated measures ANOVA compared TUG trajectories between groups, controlling for baseline age, sex, height, education level, mini mental-state examination (MMSE) score, self-reported vision and hearing, medical conditions (cardiovascular, cerebrovascular disease, diabetes), and number of medications.
findingsAt Wave 1, 1982 (58.7%) had a mean MRT of < 250 ms, with a mean TUG of 8.1 s (SD 1.6); and 1397 (41.3%) had an MRT of ≥ 250 ms, with a TUG of 9.0 s (SD 2.2). At Wave 3, TUG increased to 8.8 s (SD 2.0) and 10.2 s (SD 3.9), respectively. The results of the adjusted repeated measures ANOVA suggested that there was a statistically significant interaction between MRT group and Wave (
interpretationTILDA participants in the slower MRT group seemed to have faster mobility decline, but this effect was statistically and clinically small.
fundingTILDA is funded by Atlantic Philanthropies, the Irish Department of Health and Irish Life. Roman Romero-Ortuno is funded by Science Foundation Ireland (grant number 18/FRL/6188).
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