Evidence map›Paper›PMID 33554075›Full record

ArticleEClinicalMedicine2021

Pre-treatment optimization with pulmonary rehabilitation in lung cancer: Making the inoperable patients operable.

Ira Goldsmith, Gemma Chesterfield-Thomas, Hannah Toghill

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05863013 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Longitudinal Changes in the ADL-Glittre Test in Patients With Lung Cancer: Pre- and Postoperative Analysis Using Rehabilitation in a Randomized Controlled Trial

TypeinterventionalSponsorCentro Universitário Augusto MottaRan2023 to 2024Enrolled80ConditionsLung Cancer, Nonsmall Cell, Quality of Life, Physical Disability, SurgeryArmsADL-Glittre Test
NCT06593639 narecruitingnot on this mapstarted 2024, after this paper: background citation

Does Prehabilitation be Able to Favorably Impact on the Pathway of Head and Neck Cancer Patients, Candidate to Surgery or Chemoradiotherapy as Primary Treatment? A Prospective Clinical Trial

TypeinterventionalSponsorLaura Deborah LocatiRan2024 to 2026Enrolled60ConditionsHead and Neck CancerArmsPrehabilitation before surgery, Prehabilitation before and during CRT
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  18. Exercise in cancer patients: assistance levels and referral pathways-a position statement from the Spanish Society of Medical Oncology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ira GoldsmithDepartment of Cardiothoracic Surgery, Morriston Hospital, Swansea, Wales SA6 6NL, UK.
Gemma Chesterfield-ThomasDepartment of Physiotherapy, Morriston Hospital, Swansea, Wales SA6 6NL, UK.
Hannah ToghillDepartment of Physiotherapy, Morriston Hospital, Swansea, Wales SA6 6NL, UK.
Morriston Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnatomical lung resection offers the best prospect of long-term survival in patients with non-small cell lung cancer (NSCLC). However, some patients with significant dyspnoea, impaired performance status (PS), borderline or poor pulmonary function are considered inoperable and instead referred for radiotherapy, chemotherapy or palliative care. The aims of the study were to determine whether pre-operative pulmonary physiotherapy (Prehab), by improving clinical parameters, (i) makes patients suitable for surgery who were considered inoperable on subjective criteria of dyspnoea >3 and PS >2, and objective criteria of diffusing capacity for carbon monoxide (DLCO) <50%; and (ii) thereby allows them to safely receive curative surgery with reduced morbidity and mortality.

methodsFrom January 2017 to December 2018 a total of 306 patients were prospectively and sequentially assessed for Prehab and 216 patients with lung cancer studied. Their mean age (95% CI) was 71.7 ± 1.1 years, 50.5% (

findingsIn the total cohort following Prehab, there was significant improvement in the dyspnoea scores <2 / ≥2 (40%/60% prior to Prehab vs. 65%/35% following Prehab,

interpretationOur prospective study showed that with Prehab there was clinical and statistically significant improvement in the dyspnoea scores, PS, level of activity and frailty, particularly in the high-risk group of patients. Importantly, Prehab made previously inoperable patients operable, allowing them to safely undergo curative lung resection. This strategy helps improve resection rates and may contribute to the long term survival of lung cancer patients.

fundingThis is a Welsh Health Specialised Services Committee (WHSSC) commissioned service.

Indexed as

Abbreviations: 6MWT, Six minute walk testCOPD, Chronic obstructive pulmonary diseaseDLCODLCO, Diffusing capacity for carbon monoxideDyspnoeaFEV1, Forced expiratory volume in one secondHDU, High dependency unitInoperableIQR, Interquartile rangeLOHS, Length of hospital stayLung cancer surgeryNSCLC, Non-small cell lung cancerOperableOptimizationPerformance statusPpo, Predicted post-operative functionPrehabPrehab, Pre-operative pulmonary physiotherapyPS, Performance statusPulmonary rehabilitationVATS, Video assisted thoracoscopic surgeryWHO, World Health Organization

Identifiers

PMID33554075
PMCPMC7846708
OpenAlexW3106664583

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.