ArticleiScience2021
Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Fluorescence-activated particle sorting for condensate purification.Nature protocols · 2026Review
- Translation regulation in response to stress.The FEBS journal · 2024Review
- RNA-driven phase transitions in biomolecular condensates.Molecular cell · 2024Review
- Direct observation of translational activation by a ribonucleoprotein granule.Nature cell biology · 2024Article
- Optogenetic control of mRNA condensation reveals an intimate link between condensate material properties and functions.Nature communications · 2024Article
- Is there a localized role for translational quality control?RNA (New York, N.Y.) · 2023Article
- RNA granules: functional compartments or incidental condensates?Genes & development · 2023Review
- mRNA interactions with disordered regions control protein activity.bioRxiv : the preprint server for biology · 2023Article
- Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4Scientific reports · 2022Article
- Cotranslational Mechanisms of Protein Biogenesis and Complex Assembly in Eukaryotes.Annual review of biomedical data science · 2022Review
- Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties.iScience · 2022Article
- miR-9a regulates levels of both rhomboid mRNA and protein in the early Drosophila melanogaster embryo.G3 (Bethesda, Md.) · 2022Article
- Condensate Formation by Metabolic Enzymes inMicroorganisms · 2022Review
- It's Just a Phase: Exploring the Relationship Between mRNA, Biomolecular Condensates, and Translational Control.Frontiers in genetics · 2022Review
- Differential translation elongation directs protein synthesis in response to acute glucose deprivation in yeast.RNA biology · 2022Article
- A working model for condensate RNA-binding proteins as matchmakers for protein complex assembly.RNA (New York, N.Y.) · 2022Review
- Integrated multi-omics reveals common properties underlying stress granule and P-body formation.RNA biology · 2021Article
- Article
- mRNA Targeting, Transport and Local Translation in Eukaryotic Cells: From the Classical View to a Diversity of New Concepts.Molecular biology · 2021Article
- Hitting the mark: Localization of mRNA and biomolecular condensates in health and disease.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Glycolysis is a fundamental metabolic pathway for glucose catabolism across biology, and glycolytic enzymes are among the most abundant proteins in cells. Their expression at such levels provides a particular challenge. Here we demonstrate that the glycolytic mRNAs are localized to granules in yeast and human cells. Detailed live cell and smFISH studies in yeast show that the mRNAs are actively translated in granules, and this translation appears critical for the localization. Furthermore, this arrangement is likely to facilitate the higher level organization and control of the glycolytic pathway. Indeed, the degree of fermentation required by cells is intrinsically connected to the extent of mRNA localization to granules. On this basis, we term these granules, core fermentation (CoFe) granules; they appear to represent translation factories, allowing high-level coordinated enzyme synthesis for a critical metabolic pathway.
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Registered trials
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