Evidence map›Paper›PMID 33554067›Full record

ReviewiScience2021

How well do brain organoids capture your brain?

Jonghun Kim, Gareth J Sullivan, In-Hyun Park

Open access · goldAbstract readReview
In one paragraph

Review in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Brain organoid protocols and limitations.Frontiers in cellular neuroscience · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. iScience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jonghun KimDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine, New Haven, CT 06520, USA.
Gareth J SullivanDepartment of Molecular Medicine, Hybrid Technology Hub - Centre of Excellence, Institute of Basic Medical Sciences Norwegian Center for Stem Cell Research, Department of Pediatric Research, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
In-Hyun ParkDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine, New Haven, CT 06520, USA.
Yale Cancer Center · USOslo University Hospital · NO

Funding

Construction of the integrated human forebrain organoids to investigate neurodevelopmental disordersR01MH118344 · NIMH · YALE UNIVERSITY · PI In-Hyun Park · 2019 to 2026
$4.0M
Functional analysis of autism risk genes during neural development using single cell seqR01MH118554 · NIMH · YALE UNIVERSITY · PI GIRALDEZ, ANTONIO J · 2019 to 2023
$3.0M
Bone and Breast Cancer Molecular InteractionsR01CA203011 · NCI · YALE UNIVERSITY · PI LEE, FRANCIS YOUNG-IN · 2016 to 2020
$2.3M
Brain microRNA-mRNA regulatory networks and alcohol use disordersR01AA025080 · NIAAA · YALE UNIVERSITY · PI ZHANG, HUIPING · 2016 to 2020
$1.7M
Investigation of the function of methylated DNA binding protein in reprogrammingR01GM111667 · NIGMS · YALE UNIVERSITY · PI PARK, IN-HYUN · 2014 to 2018
$1.6M
NCI NIH HHS R01 CA203011NIAAA NIH HHS R01 AA025080NIGMS NIH HHS R01 GM111667NIMH NIH HHS R01 MH118344NIMH NIH HHS R01 MH118554
6 · The paper itself

Abstract

Brain organoids closely recapitulate many features and characteristics of

Indexed as

neurosciencetissue engineering

Identifiers

PMID33554067
PMCPMC7856464
OpenAlexW3123504158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.