Evidence map›Paper›PMID 33554057›Full record

ArticleiScience2021

Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P)

Ju-Yi Hsieh, Hao-Ping Yang, Sunil Kumar Tewary, Hui-Chen Cheng, Yi-Liang Liu, Shih-Chieh Tai, Wei-Lin Chen, Chien-Hui Hsu, Ting-Jhen Huang, Chuan-Jung Chou and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. A cryptic allosteric pocket shapes isoform-selective inhibition of human malic enzymes.Protein science : a publication of the Protein Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Ju-Yi HsiehDepartment of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
Hao-Ping YangDepartment of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
Sunil Kumar TewaryInstitute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Hui-Chen ChengDepartment of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
Yi-Liang LiuDepartment of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
Shih-Chieh TaiDepartment of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
Wei-Lin ChenDepartment of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
Chien-Hui HsuDepartment of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
Ting-Jhen HuangDepartment of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
Chuan-Jung ChouDepartment of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
Yu-Nan HuangDepartment of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
Ching-Tien PengDivision of Pediatric Hematology and Oncology, China Medical University Children's Hospital, Taichung, Taiwan.
Meng-Chiao HoInstitute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Guang-Yaw LiuInstitute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Hui-Chih HungDepartment of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
National Chung Hsing University · TWNational Taiwan University · TWChina Medical University · TWChung Shan Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human mitochondrial NAD(P)

Indexed as

Biological SciencesCancerCell BiologyGeneticsStructural Biology

Identifiers

PMID33554057
PMCPMC7847962
OpenAlexW3118709752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.