Evidence map›Paper›PMID 33553829›Full record

ArticleBioactive materials2021

Milk exosomes: Nature's abundant nanoplatform for theranostic applications.

Benilde Adriano, Nycol M Cotto, Neeraj Chauhan, Meena Jaggi, Subhash C Chauhan, Murali M Yallapu

Abstract read
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benilde AdrianoDepartment of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA.
Nycol M CottoDepartment of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA.
Neeraj ChauhanDepartment of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA.
Meena JaggiDepartment of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA.
Subhash C ChauhanDepartment of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA.
Murali M YallapuDepartment of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX, 78504, USA.

Funding

MUC13 Mucin in Colorectal Cancer Health DisparityR01CA204552 · NCI · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI CHAUHAN, SUBHASH C. · 2016 to 2020
$1.7M
Development of Targeted Nanotechnology Platform for Pancreatic CancerR01CA206069 · NCI · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI CHAUHAN, SUBHASH C. · 2016 to 2021
$1.7M
Targeted Nanotherapy for Pancreatic CancerR01CA210192 · NCI · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI CHAUHAN, SUBHASH C. · 2016 to 2021
$1.7M
NCI NIH HHS R01 CA204552NCI NIH HHS R01 CA206069NCI NIH HHS R01 CA210192
6 · The paper itself

Abstract

Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles. Exosomes have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, and disseminating long-distance intercellular communications in various biological processes. Among various cell-line or biological fluid derived exosomes, milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications. To be an effective delivery carrier for their clinical translation, exosomes must inbuilt loading, release, targeting, and imaging/tracking characteristics. Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging applications. This review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery approaches. It is emphasized on possible modifications of exosomes towards increasing the stability and delivery of agents. This article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle.

Indexed as

Drug deliveryExtracellular vesiclesImaging agentsMilk exosomesTheranostic applications

Identifiers

PMID33553829
PMCPMC7856328

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.