Evidence map›Paper›PMID 33553772›Full record

ArticleHeliyon2021

A flow cytometric assay for the quantification of MSC lysis by peripheral blood mononucleated cells.

Katia Chieregato, Martina Bernardi, Alberta Alghisi, Rosaria Giordano, Lorenza Lazzari, Omar Perbellini, Mario Rassu, Marco Ruggeri, Giuseppe Astori

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Katia ChieregatoAdvanced Cellular Therapy Laboratory, Haematology Unit, Vicenza Hospital, Italy.
Martina BernardiAdvanced Cellular Therapy Laboratory, Haematology Unit, Vicenza Hospital, Italy.
Alberta AlghisiImmunohematology and Transfusion Medicine Service, Vicenza Hospital, Italy.
Rosaria GiordanoLaboratory of Regenerative Medicine - Cell Factory, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Lorenza LazzariLaboratory of Regenerative Medicine - Cell Factory, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Omar PerbelliniAdvanced Cellular Therapy Laboratory, Haematology Unit, Vicenza Hospital, Italy.
Mario RassuDepartment of Microbiology, Vicenza Hospital, Italy.
Marco RuggeriAdvanced Cellular Therapy Laboratory, Haematology Unit, Vicenza Hospital, Italy.
Giuseppe AstoriAdvanced Cellular Therapy Laboratory, Haematology Unit, Vicenza Hospital, Italy.
International Renal Research Institute of Vicenza · ITConsorzio per la Ricerca Sanitaria · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stromal cells (MSC) are attractive candidates for the treatment of acute graft versus host disease (aGvHD) or autoimmune disorders. However, mechanisms of MSC recognition remain unclear and there are evidences that MSC are not totally immunoprivileged. Data suggest that MSC undergo apoptosis after infusion in presence of cytotoxic cells and their death could drive immunosuppression. In GvHD patients, that activity was associated with clinical response. It is mandatory to develop an

Indexed as

Absolute countApoptosisCytotoxicityGraft versus host diseaseMesenchymal stromal cell

Identifiers

PMID33553772
PMCPMC7856420
OpenAlexW3128740869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.