ArticleHeliyon2021
Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss.
Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Plant-Mediated Silver Nanoparticle Formulations for Wound Healing: A Process-Property-Performance Perspective.Pharmaceutics · 2026Review
- Role of a topical hydrogel (DermatixDrugs in context · 2026Review
- Optimizing a Natural Oil-Based Sertaconazole Nitrate Organogel: enhanced antifungal activity throughJournal of pharmacopuncture · 2025Article
- QbD Optimized Nanoemulsion Based Topical Formulation of Jatyadi Taila: Unveiling its In Vitro and In Vivo Efficacy for Enhanced Wound Healing.Pharmaceutical research · 2025Article
- Porous Silicon Nanoparticle Hydrogel Formulation for Topical Delivery of Flightless I Neutralizing Antibody and Improved Diabetic Wound Healing.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Improving Vaginal Health with a Zinc-Containing Vaginal Hydrogel.Gels (Basel, Switzerland) · 2025Article
- Development and Bioavailability Assessment of an Estriol-Containing Vaginal Hydrogel.Gels (Basel, Switzerland) · 2024Article
- Sensitization to Lanolin in North-Eastern Italy, 1997-2021: Prevalence, Risk Factors and the Impact of Occupation.Life (Basel, Switzerland) · 2024Article
- Article
- Comparative Study of the Efficacy of EHO-85, a Hydrogel Containing Olive Tree (International journal of molecular sciences · 2023Article
- Acceleration of Wound Healing in Rats by Modified Lignocellulose Based Sponge Containing Pentoxifylline Loaded Lecithin/Chitosan Nanoparticles.Gels (Basel, Switzerland) · 2022Article
- Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence.Journal of clinical medicine · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFive different galenics were analyzed and compared concerning tissue breathability and gas exchange with the environment after an application period of 6 h on pig ear skin. Aim was to find the most suitable galenics for efficient moist treatment for everyday injuries (abrasions, lacerations and cuts) without influencing the transepidermal water loss.
methodsA quantity of 0.1 g of the different test preparations was applied once topically to an area of 2 cm
resultsThe hydrogel preparations showed a higher breathability in contrast to a semi-occlusive ointment and petrolatum. The same applies to the moisture penetration of the skin. Here, all hydrogel formulations showed the highest tissue hydration. After 3 h an additional increase in moisture was observed for the areas treated with Tyrosur® CareExpert Wound Gel and the ointment.
conclusionIn contrast to petrolatum and the semi-occlusive ointment, treatment with the hydrogels led to a preservation of the breathability and good moistening of the tissue, which is due to the galenics of the gels consisting of water, carbomer and propylene glycol. The increase in moisture after 3 h in areas treated with Tyrosur® CareExpert Wound Gel and the semi-occlusive ointment indicates a sustained moisturizing effect mediated by dexpanthenol.
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