ArticleJournal of clinical tuberculosis and other mycobacterial diseases2021
Diagnostic implications and inpatient mortality related to tuberculosis at Jimma Medical Center, southwest Ethiopia.
Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Factors associated with severity of pulmonary tuberculosis in people living with and without HIV: a systematic review.BMC infectious diseases · 2026Pooled it
- Clinically diagnosed tuberculosis and mortality in high burden settings: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- A predictive score for early in-patient tuberculosis mortality: A case-control study.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Diagnosis and Management of Adult Tuberculosis Patients Admitted to a Rural Hospital in Ethiopia.Cureus · 2023Article
- The Burden of Bacteriologically Negative TB Diagnosis: A Four-Year Review of Tuberculosis Cases at a Tertiary Facility.Tuberculosis research and treatment · 2023Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundTuberculosis (TB) is one of the major public health problems in Ethiopia. Determining discharge outcome of TB cases helps to understand the effectiveness of TB diagnosis effort to improve case management. The objective of this study was to assess discharge outcomes and factors associated with death among patients on TB treatment admitted in a referral hospital in southwest Ethiopia.
methodsA retrospective study was conducted in Jimma Medical Center by reviewing medical records of TB patients (age ≥15 years) admitted to medical wards from January 2015 to December 2017. Demographic and related data was collected using data collection format. The clinical evaluation outcome of an individual patient at discharge was recorded. Descriptive statistics were used to summarize participant characteristics. Multivariate logistic regression analyses were used to evaluate the risk factors for TB mortality.
resultsAmong 465 patients included in the review, 225 (48.4%) were pulmonary (PTB) and 240 (51.6%) extra-pulmonary TB (EPTB) cases. Overall, 190 (40.9%) had bacteriologically confirmed for TB. HIV status was documented for 340 (73.1%) of them; 93 (27.4%) were found to be positive. The prevalence of HIV infection among EPTB and PTB cases was 50/275 (18.2%) and 43/190 (22.8%), respectively. A quarter of the patient, 114 (24.5%), died in the hospital while the rest were discharged with clinical improvement. Compared to smear positive PTB, the risk of death was two times higher in patients with smear negative PTB cases (aOR 2.3, 95% CI: 1.3-4.2). TB patients with coronary obstructive pulmonary disease (COPD) (aOR 4.6, 95% CI: 1.3-16.7), diabetes mellitus (aOR 5.7, 95% CI: 1.5-23.7), heart disease (aOR 3.8, 95% CI: 1.4-10.4) had about four-fold increased risk of death. HIV-positive patients had a higher risk of mortality (aOR 2.9, 95% CI: 1.7-5.0) than HIV-negative patients. The risk of death was not affected by the type of TB diagnosed, as 27.6% of EPTB and 31.9% PTB were died (p = 0.457).
conclusionTB was associated with high inpatient mortality at Jimma Medical Center. Mortality was found to be higher among unconfirmed cases, those with COPD, diabetes mellitus, heart disease and HIV infection. Thus, any effort to curtail mortality in such high TB burden setting should focus on improving TB diagnosis and addressing major comorbid medical conditions.
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