Evidence map›Paper›PMID 33553608›Full record

ArticleMolecular & cellular oncology2021

Roles of SDE2 and TIMELESS at active and stalled DNA replication forks.

Natalie Lo, Julie Rageul, Hyungjin Kim

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. A nine-gene signature as prognostic biomarker in gastric cancer by bioinformatics analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Article
  4. Comprehensive Effects ofFrontiers in plant science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Natalie LoDepartment of Pharmacological Sciences, The State University of New York at Stony Brook, Stony Brook, NY, USA.
Julie RageulDepartment of Pharmacological Sciences, The State University of New York at Stony Brook, Stony Brook, NY, USA.
Hyungjin KimDepartment of Pharmacological Sciences, The State University of New York at Stony Brook, Stony Brook, NY, USA.ORCID https://orcid.org/0000-0003-1913-6373
State University of New York · US

Funding

Proteolytic control of DNA interstrand cross-link repair and genome integrityR01CA218132 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI KIM, HYUNGJIN · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA218132
6 · The paper itself

Abstract

The fork protection complex (FPC), comprising the TIMELESS (TIM)-TIPIN heterodimer, acts as a scaffold of the replisome to support seamless DNA replication. We recently showed that SDE2, a PCNA-associated DNA replication stress regulator, maintains the integrity of the FPC, and together with TIM, protects stalled replication forks from nucleolytic degradation.

Indexed as

BRCA1/BRCA2DNA replication stressfork protection complexGenome instabilitySDE2TIMELESS

Identifiers

PMID33553608
PMCPMC7849734
OpenAlexW3113350630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.