ArticleMovement disorders clinical practice2021
Prevalence of Non-Motor Symptoms and Non-Motor Fluctuations in Parkinson's Disease Using the MDS-NMS.
Article in Movement disorders clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Diagnosis and treatment of autonomic failure, pain and sleep disturbances in Parkinson's disease: guideline "Parkinson's disease" of the German Society of Neurology.Journal of neurology · 2025Guideline
- Relationships between physical activities performed under free-living conditions and non-motor symptoms in people with Parkinson's: A systematic review and meta-analysis.Clinical rehabilitation · 2024Pooled it
- The effect of two speech and language approaches on speech problems in people with Parkinson's disease: the PD COMM RCT.Health technology assessment (Winchester, England) · 2024Trial
- Long-term safety, tolerability and efficacy of apomorphine sublingual film in patients with Parkinson's disease complicated by OFF episodes: a phase 3, open-label study.Journal of neurology · 2024Trial
- On-demand therapies-emergency medication or daily routine?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Hoehn and Yahr Stage and Non-Motor Symptom Burden in Parkinson's Disease: A Cross-Sectional Study in Peru.Medicina (Kaunas, Lithuania) · 2026Article
- The Influence of Motor and Nonmotor Factors on Ambulatory Activity in People With Parkinson Disease.Journal of neurologic physical therapy : JNPT · 2026Article
- Impact of non-motor symptoms on the quality of life of Parkinson's disease patients in a cohort of Senegalese patients.BMC neurology · 2026Article
- Neurometabolic Signatures of Alexithymia and Visuospatial Abilities in Parkinson's Disease: An ExploratoryJournal of clinical medicine · 2026Article
- Validation of the German Version of the Movement Disorder Society Non-Motor Scale (MDS-NMS).Movement disorders clinical practice · 2026Article
- Non-motor fluctuations in Parkinson's disease: frequency and clinical correlate.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Spermidine Suppresses Peripheral Inflammation and Alleviates Non-Motor Symptoms in the 6-OHDA-Induced Rat Model of Parkinson's Disease.Molecules (Basel, Switzerland) · 2026Article
- Antipsychotic Medications in Parkinson's Disease Psychosis; A Systematic Review of Double-Blind, Randomised, Placebo-Controlled Trials.Healthcare (Basel, Switzerland) · 2026Review
- Motor and non-motor fluctuations in Parkinson's disease: the knowns and unknowns of current therapeutic approaches.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Cross-cultural adaptation, reliability, and preliminary construct validity of the Japanese version of the Parkinson's disease pain classification system.Clinical parkinsonism & related disorders · 2026Article
- A transdiagnostic approach to non-motor symptoms in Parkinson's disease: exploring internalizing, bipolar spectrum, and impulsive compulsive behavior profiles via cluster analysis.Frontiers in aging neuroscience · 2026Article
- Review
- Article
- A Real-World Study on Unstable Parkinson's Disease: Levodopa Dosage Management and the Role of Nonmotor Symptoms.Movement disorders clinical practice · 2025Article
- Nonmotor fluctuations in Parkinson's disease: impact on caregiving and quality of life.Journal of neurology · 2025Observational
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-motor symptoms (NMS) are frequent in Parkinson's disease (PD).
objectivesTo estimate the prevalence of NMS and of non-motor fluctuations (NMF) using the Movement Disorders Society-Non-Motor Rating Scale (MDS-NMS) and other scales assessing NMS, and their relationship with sex and PD severity.
methodsCross-sectional study with a sample of 402 PD patients. The Hoehn and Yahr staging system (HY), Clinical Impression of Severity Index for PD (CISI-PD), MDS-NMS (including NMF- subscale), Non-Motor Symptoms scale (NMSS), and MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) were applied. A NMS was considered present when scored ≥1. Differences in scores by sex and HY, CISI-PD, and MDS-UPDRS severity levels were calculated using Fisher's exact and chi-squared tests.
resultsUsing the MDS-NMS, NMS were present in 99.7% of patients and the mean number of NMS was 16.13 (SD: 9.36). The most prevalent NMS was muscle, joint or back pain (67.4% of the sample) and the least prevalent was dopamine dysregulation syndrome (2.2%). Feeling sad or depressed was significantly more prevalent in women. Using the MDS-NMS revealed more NMS than the other scales assessing NMS. NMF were present in 41% of the sample, with fatigue being the most prevalent symptom (68.5% patients with NMF), and no differences by sex. Patients with greater PD severity had higher prevalence of NMS than patients with lower severity.
conclusionsAlmost all patients with PD experience NMS, and many experience NMF. Prevalence rates for NMS using the MDS-NMS are higher than on other scales used and increase with higher disease severity.
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