Evidence map›Paper›PMID 33553478›Full record

ArticleOpen forum infectious diseases2021

Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases.

Heather W Dolby, Philippe Potey, Annika B Wilder-Smith, Sara Clohisey, Jonathan E Millar, J Kenneth Baillie, David A Dorward, Christopher D Lucas, Clark D Russell

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19.American journal of respiratory cell and molecular biology · 2022
    Article
  7. Pulmonary macrophages and SARS-Cov2 infection.International review of cell and molecular biology · 2022
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Heather W DolbyUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
Philippe PoteyUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
Annika B Wilder-SmithUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
Sara ClohiseyRoslin Institute, Division of Genetics and Genomics, University of Edinburgh, Edinburgh, United Kingdom.
Jonathan E MillarRoslin Institute, Division of Genetics and Genomics, University of Edinburgh, Edinburgh, United Kingdom.
J Kenneth BaillieRoslin Institute, Division of Genetics and Genomics, University of Edinburgh, Edinburgh, United Kingdom.
David A DorwardUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
Christopher D LucasUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
Clark D RussellUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.ORCID 0000-0002-9873-8243
Queen's Medical Centre · GBRoslin Institute · GB

Funding

Chief Scientist Office COV/EDI/20/10Medical Research Council MC_PC_19025Medical Research Council MC_PC_19059Wellcome Trust
6 · The paper itself

Abstract

Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n  =  455 patients), severe acute respiratory syndrome ([SARS] n  =  37), Middle East respiratory syndrome (n  =  2), adenovirus (n  =  34), and respiratory syncytial virus (n  =  30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.

Indexed as

acute respiratory distress syndromeinfluenzaSARS coronavirusthrombosisvasculitis

Identifiers

PMID33553478
PMCPMC7798721
OpenAlexW3116984155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.