ArticleAnnals of translational medicine2021
Disrupted balance of long and short-range functional connectivity density in Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients: a resting-state fMRI study.
Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Neuroimaging studies of acupuncture on Alzheimer's disease: a systematic review.BMC complementary medicine and therapies · 2023Pooled it
- Interpretable multimodal MRI fusion in Alzheimer's disease classification using extended parallel multilink joint ICA and 3D ResNet.iScience · 2026Article
- Dynamics of brain connectivity across the Alzheimer's disease spectrum through magnetoencephalography.Scientific reports · 2026Article
- Investigating Disruptions in Information Flow due to Sickle Cell Disease Using Granger Causality.Human brain mapping · 2025Article
- Dual task reactive balance control in older adults with mild cognitive impairment: does the cognitive task domain make a difference?Journal of neurophysiology · 2025Article
- The characteristic pattern of functional connectivity density influenced by postmenopausal females in the preclinical stage of dementia.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Altered Density of Resting-State Long- and Short-Range Functional Connectivity in Patients with Moderate-to-Severe Obstructive Sleep Apnea.Nature and science of sleep · 2024Article
- Disrupted Balance of Short- and Long-Range Functional Connectivity Density in Patients with Herpes Zoster or Postherpetic Neuralgia: A Resting-State fMRI Study.Journal of pain research · 2024Article
- fMRI-based Alzheimer's disease detection via functional connectivity analysis: a systematic review.PeerJ. Computer science · 2024Article
- Abnormal functional connectivity density involvement in freezing of gait and its application for subtyping Parkinson's disease.Brain imaging and behavior · 2023Article
- Local Brain Network Alterations and Olfactory Impairment in Alzheimer's Disease: An fMRI and Graph-Based Study.Brain sciences · 2023Article
- Identifying Alzheimer's disease and mild cognitive impairment with atlas-based multi-modal metrics.Frontiers in aging neuroscience · 2023Article
- Disrupted Balance of Gray Matter Volume and Directed Functional Connectivity in Mild Cognitive Impairment and Alzheimer's Disease.Current Alzheimer research · 2023Article
- Causal functional connectivity in Alzheimer's disease computed from time series fMRI data.Frontiers in computational neuroscience · 2023Article
- Cerebello-cortical functional connectivity may regulate reactive balance control in older adults with mild cognitive impairment.Frontiers in neurology · 2023Article
- A Multi-Modal and Multi-Atlas Integrated Framework for Identification of Mild Cognitive Impairment.Brain sciences · 2022Article
- Associations between disrupted functional brain network topology and cognitive impairment in patients with rectal cancer during chemotherapy.Frontiers in oncology · 2022Article
- Pre-diabetes is associated with altered functional connectivity density in cortical regions of the default-mode network.Frontiers in aging neuroscience · 2022Article
- Corrigendum: Regional homogeneity in patients with mild cognitive impairment: A resting-state functional magnetic resonance imaging study.Frontiers in aging neuroscience · 2022Article
- The altered functional connectivity density related to cognitive impairment in alcoholics.Frontiers in psychology · 2022Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlzheimer's disease (AD) is an age-progressive neurodegenerative disorder that affects cognitive function. There have been several functional connectivity (FC) strengths; however, FC density needs more development in AD. Therefore, this study wanted to determine the alternations in resting-state functional connectivity density (FCD) induced by Alzheimer's and mild cognitive impairment (MCI).
methodsOne hundred and eleven AD patients, 29 MCI patients, and 73 healthy controls (age- and sex-matched) were recruited and assessed using resting-state functional magnetic resonance imaging (MRI) scanning. The ultra-fast graph theory called FCD mapping was used to calculate the voxel-wise short- and long-range FCD values of the brain. We performed voxel-based between-group comparisons of FCD values to show the cerebral regions with significant FCD alterations. We performed Pearson's correlation analyses between aberrant functional connectivity densities and several clinical variables with adjustment for age and sex.
resultsPatients with cognition decline showed significantly abnormal long-range FCD in the cerebellum crus I, right insula, left inferior frontal gyrus, left superior frontal gyrus, left inferior frontal gyrus, and right middle frontal gyrus. The short-range FCD changed in the cerebellum crus I, left inferior frontal gyrus, left superior occipital gyrus, and right middle frontal gyrus. The long- and short-range functional connectivity in the left inferior frontal gyrus was positively correlated with Mini-mental State Examination (MMSE) scores.
conclusionsFCD in the identified regions reflects mechanism and compensation for loss of cognitive function. These findings could improve the pathology of AD and MCI and supply a neuroimaging marker for AD and MCI.
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