ArticleAnnals of translational medicine2021
Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients-a pilot clinical study.
Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cross-sectional Study of Calf Muscle Perfusion in Patients With Intermittent Claudication by Non-invasive Multispectral Optoacustic Tomography
Cross-sectional Study of Calf Muscle Perfusion Via 3D Reconstruction of Multispectral Optoacoustic Tomography in Patients With Peripheral Arterial Disease After Exercise.
Evaluation of Gluteal Muscle Perfusion in Patients With Intermittent Gluteal Claudication by Non-invasive Multispectral Optoacoustic Tomography With Pre-post Study Design
Study of Calf Muscle Perfusion in Patients With Peripheral Arterial Disease After Revascularization Procedure Using Multispectral Optoacoustic Tomography
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Image Quality Improvement Techniques and Assessment Adequacy in Clinical Optoacoustic Imaging: A Systematic Review.Biosensors · 2022Pooled it
- Optoacoustic muscle imaging.Journal of neuromuscular diseases · 2026Review
- Mapping glucose-induced hemodynamics in white fat depots with label-free optoacoustics.Photoacoustics · 2026Article
- Blood-mimicking dye phantoms for evaluating photoacoustic oximetry accuracy.Photoacoustics · 2026Article
- Development of a Dual Photoacoustic-Ultrasound Imaging System: Current Status and Future Perspectives.Sensors (Basel, Switzerland) · 2026Review
- Hemoglobin and human longevity: integrating oxygen transport, redox biology, and aging pathways - a narrative review.Annals of medicine and surgery (2012) · 2026Review
- Multispectral optoacoustic tomography of salivary glands in patients with clinically suspected Sjögren's disease: A pilot study.Photoacoustics · 2025Article
- High-resolution three-dimensional quantitative photoacoustic and ultrasound imaging of subcutaneous microvasculature in extremities.Biomedical optics express · 2025Article
- Optoacoustic imaging in lower extremity revascularization: A novel technique to assess perioperative muscle perfusion.Photoacoustics · 2025Article
- Light and metabolism: label-free optical imaging of metabolic activities in biological systems [Invited].Biomedical optics express · 2025Review
- Photoacoustic-Strain (PAS) Imaging for Tissue Microcirculation Assessment.IEEE transactions on medical imaging · 2025Article
- Recent advancements in molecular photoacoustic tomography.JPhys photonics · 2025Review
- A fast all-optical 3D photoacoustic scanner for clinical vascular imaging.Nature biomedical engineering · 2025Article
- Derivation and validation of a non-invasive optoacoustic imaging biomarker for detection of patients with intermittent claudication.Communications medicine · 2025Article
- A primer on current status and future opportunities of clinical optoacoustic imaging.Npj imaging · 2025Review
- Emerging Photoacoustic Imaging Techniques for Peripheral Arterial Disease.Current treatment options in cardiovascular medicine · 2025Review
- Scanning optoacoustic angiography for assessing structural and functional alterations in superficial vasculature of patients with post-thrombotic syndrome: A pilot study.Photoacoustics · 2024Article
- Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease.Photoacoustics · 2024Article
- Mini review of photoacoustic clinical imaging: a noninvasive tool for disease diagnosis and treatment evaluation.Journal of biomedical optics · 2024Review
- Clinical and Translational Imaging and Sensing of Diabetic Microangiopathy: A Narrative Review.Journal of cardiovascular development and disease · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent imaging assessment of peripheral artery disease (PAD) relies on anatomical cross-sectional visualizations of the affected arteries. Multispectral optoacoustic tomography (MSOT) is a novel molecular imaging technique that provides direct and label-free visualizations of soft tissue perfusion and oxygenation.
methodsMSOT was prospectively assessed in a pilot trial in healthy volunteers (group n
resultsCalf measurements in healthy volunteers revealed distinct dynamics for HbO
conclusionsClinical MSOT allows for non-invasive, label-free and real-time imaging of muscle oxygenation in health and disease with implications for diagnostics and therapy assessment in PAD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.