ArticleAnnals of translational medicine2021
Association between comorbid diabetes mellitus and prognosis of patients with sepsis in the intensive care unit: a retrospective cohort study.
Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diabetes mellitus and mortality in patients admitted to ICU with sepsis: a meta-analysis.Frontiers in medicine · 2026Pooled it
- Etiology of bloodstream infections in adult diabetic patients from a single tertiary hospital in southern Vietnam: a retrospective study.Tropical medicine and health · 2026Article
- Risk Factors for Mortality in Critically Ill Patients with Diabetes Admitted to the ICU: A Single-Center Retrospective Observational Study.Journal of clinical medicine · 2026Article
- Effector function and neutrophil cell death in the severity of sepsis with diabetes mellitus.Narra J · 2024Review
- In-Hospital Hyperglycemia Is Associated With Worse Outcomes in Patients Admitted With COVID-19.Diabetes care · 2022Article
- Impact of diabetes mellitus on outcomes of patients with sepsis: an updated systematic review and meta-analysis.Diabetology & metabolic syndrome · 2022Review
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4 authors.
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Abstract
backgroundSepsis patients hospitalized in the intensive care unit (ICU) often have comorbid diabetes mellitus (DM). However, the clinical impact of DM on the clinical outcomes of critically ill sepsis patients has yet to be determined. Therefore, the current study aimed to analyze the association of comorbid DM with the prognosis of sepsis patients in the ICU.
methodsData of patients with sepsis and comorbid DM were obtained from a large-scale intensive care database. The primary outcome was 28-day mortality after ICU admission. Associations of comorbid DM with the primary outcome were assessed using a multivariable Cox regression model. Different adjusted models, such as the propensity score method, were used to determine the prognosis of the patients.
resultsOverall, 12,321 sepsis patients were enrolled, including 3,509 (28.48%) with comorbid DM. After adjusting and matching, we found that comorbid DM was not an independent risk factor for 28-day mortality in critically ill sepsis patients and was even associated with lower mortality. Propensity score matching showed a dramatically lower 28-day mortality for sepsis patients with comorbid DM in comparison to patients without comorbid DM [hazard ratio (HR): 0.86, 95% confidence interval (CI): 0.77-0.97, P=0.0167]. The relationship of comorbid DM with 28-day mortality was broadly consistent for all subgroup variables. In the stratified analysis, a significant interaction was observed only for glucose concentration (P<0.0001). Patients with comorbid DM and a glucose level of 140-200 mg/dL (7.8-11.1 mmol/L) or ≥200 mg/dL (11.1 mmol/L) had a significantly lower 28-day mortality rate (HR 0.83, 95% CI: 0.71-0.98, P=0.0250 and HR: 0.49, 95% CI: 0.38-0.64, P<0.0001, respectively).
conclusionsCritically ill patients with sepsis and comorbid DM were not found to have increased 28-day mortality compared to those without comorbid DM, and may even have a lower risk of mortality. Notably, this association remained in the setting of hyperglycemia.
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