Evidence map›Paper›PMID 33553169›Full record

ReviewFrontiers in cell and developmental biology2020

Zebrafish: A Model Organism for Studying Enteric Nervous System Development and Disease.

Laura E Kuil, Rajendra K Chauhan, William W Cheng, Robert M W Hofstra, Maria M Alves

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Enteroendocrine cells wire the gut-brain vagal axis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. International journal of molecular sciences · 2026
    Article
  9. Article
  10. Article
  11. Whole-Gut Spatial Genomic Analysis Reveals Molecular Regionalization of the Differentiating Zebrafish Enteric Nervous System.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Biomedicines · 2025
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laura E KuilDepartment of Clinical Genetics, Erasmus University Medical Centre, Rotterdam, Netherlands.
Rajendra K ChauhanDepartment of Clinical Genetics, Erasmus University Medical Centre, Rotterdam, Netherlands.
William W ChengDepartment of Clinical Genetics, Erasmus University Medical Centre, Rotterdam, Netherlands.
Robert M W HofstraDepartment of Clinical Genetics, Erasmus University Medical Centre, Rotterdam, Netherlands.
Maria M AlvesDepartment of Clinical Genetics, Erasmus University Medical Centre, Rotterdam, Netherlands.
University College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Enteric Nervous System (ENS) is a large network of enteric neurons and glia that regulates various processes in the gastrointestinal tract including motility, local blood flow, mucosal transport and secretion. The ENS is derived from stem cells coming from the neural crest that migrate into and along the primitive gut. Defects in ENS establishment cause enteric neuropathies, including Hirschsprung disease (HSCR), which is characterized by an absence of enteric neural crest cells in the distal part of the colon. In this review, we discuss the use of zebrafish as a model organism to study the development of the ENS. The accessibility of the rapidly developing gut in zebrafish embryos and larvae, enables

Indexed as

CRISPR/Cas9drugscreenfunctional geneticsgastrointestinal systemgut transitHirschsprung diseasemorpholinozebrafish

Identifiers

PMID33553169
PMCPMC7859111
OpenAlexW3122738671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.