ReviewFrontiers in cell and developmental biology2020
Anatomy and Development of the Mammalian External Auditory Canal: Implications for Understanding Canal Disease and Deformity.
Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Characterizing Age Effects on Wideband Absorbance in Normal-Hearing Children Via Statistical and Machine Learning Analyses.Journal of otology · 2026Article
- Effectiveness of the Temporal Flap in Reconstruction After Advanced External Ear Tumor Resection: A Case Report.Clinics and practice · 2026Article
- Ear-Rational Behavior: A Survey Study of Q-tip (Cotton Swab) Habits and Health Perceptions.Cureus · 2025Article
- The feasibility of endoscopic stapes surgery: A three-dimensional planning method.Laryngoscope investigative otolaryngology · 2025Review
- Postoperative recurrence of traumatic acquired external auditory canal atresia: a case report.American journal of translational research · 2025Article
- Hearables: Bioelectronics technological challenges and opportunities.Wearable technologies · 2025Review
- Ear Reconstruction following Mohs Micrographic Surgery.Seminars in plastic surgery · 2024Review
- Biomedical application of materials for external auditory canal: History, challenges, and clinical prospects.Bioactive materials · 2024Review
- Advancements in Pediatric Audiological Assessments Using Wideband Acoustic Immittance: A Review.Audiology research · 2024Review
- The role of the microbiome in allergic dermatitis-related otitis externa: a multi-species comparative review.Frontiers in veterinary science · 2024Review
- Clinical manifestations and treatment strategies for congenital aural atresia with temporomandibular joint retroposition: a retrospective study of 30 patients.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023Article
- Ecological correlates of the morphology of the auditory bulla in rodents: Application to the fossil record.Journal of anatomy · 2022Article
- The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa.Disease models & mechanisms · 2022Article
- Variants and Modifications of the Retroauricular Approach Using in Temporomandibular Joint Surgery: A Systematic Review.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian ear is made up of three parts (the outer, middle, and inner ear), which work together to transmit sound waves into neuronal signals perceived by our auditory cortex as sound. This review focuses on the often-neglected outer ear, specifically the external auditory meatus (EAM), or ear canal. Within our complex hearing pathway, the ear canal is responsible for funneling sound waves toward the tympanic membrane (ear drum) and into the middle ear, and as such is a physical link between the tympanic membrane and the outside world. Unique anatomical adaptations, such as its migrating epithelium and cerumen glands, equip the ear canal for its function as both a conduit and a cul-de-sac. Defects in development, or later blockages in the canal, lead to congenital or acquired conductive hearing loss. Recent studies have built on decades-old knowledge of ear canal development and suggest a novel multi-stage, complex and integrated system of development, helping to explain the mechanisms underlying congenital canal atresia and stenosis. Here we review our current understanding of ear canal development; how this biological lumen is made; what determines its location; and how its structure is maintained throughout life. Together this knowledge allows clinical questions to be approached from a developmental biology perspective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.