Evidence map›Paper›PMID 33553141›Full record

ArticleFrontiers in cell and developmental biology2020

Estrogen Receptor Beta Prevents Signet Ring Cell Gastric Carcinoma Progression in Young Patients by Inhibiting Pseudopodia Formation via the mTOR-Arpc1b/EVL Signaling Pathway.

Xingzhou Wang, Xuefeng Xia, En Xu, Zhi Yang, Xiaofei Shen, Shangce Du, Xiaotong Chen, Xiaofeng Lu, Wei Jin, Wenxian Guan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xingzhou WangDepartment of General Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Xuefeng XiaDepartment of General Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
En XuDepartment of General Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Zhi YangDepartment of General Surgery, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing, China.
Xiaofei ShenDepartment of General Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Shangce DuDepartment of General Surgery, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing, China.
Xiaotong ChenComprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, China.
Xiaofeng LuDepartment of General Surgery, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing, China.
Wei JinDepartment of Neurosurgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Wenxian GuanDepartment of General Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Nanjing Drum Tower Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Signet ring cell gastric carcinoma (SRCGC) is a poorly differentiated malignancy, and can be highly dangerous in the progression stage. There is a higher male to female ratio among patients with signet ring cell carcinoma as compared to patients with non-SRCGC. ERβ has been found to express in stomach adenocarcinoma, but how it affects tumor progression remains unclear. Here, we studied estrogen receptor beta (ERβ) to explore the role of sex-associated factors in SRCGC. We analyzed the clinicopathological statistics of patients with SRCGC, and conducted a series of

Indexed as

clinicopathologic analysisestrogen receptor beta (ERß)mTORpseudopodiasignet ring cell gastric carcinoma

Identifiers

PMID33553141
PMCPMC7859346
OpenAlexW3122580053

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.