ArticleFrontiers in bioengineering and biotechnology2020
The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI.
Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Lumbar disc herniation modelling: a review of ex-vivo mechanical models and a comparison with clinical data.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Pooled it
- Intervertebral Disc Elastography to Relate Shear Modulus and Relaxometry in Compression and Bending.Bioengineering (Basel, Switzerland) · 2026Article
- The effect of spaceflight on tissues of the spinal column.Bone reports · 2026Review
- Article
- Biomechanical analysis of medial tibial cartilage by 7T magnetic resonance imaging and digital volume correlation: a preliminary study of variations caused meniscus ramp lesions.Journal of orthopaedic surgery and research · 2025Article
- Multiaxial rotational loading compromises the transition zone of the intervertebral disc: Ex vivo study using next-generation bioreactors.Bioengineering & translational medicine · 2025Article
- Comparative outcomes of unilateral biportal endoscopic lumbar intervertebral discectomy with and without annulus fibrosus suture in lumbar disc herniation: a retrospective analysis.Frontiers in surgery · 2025Article
- Article
- Review
- Disc degeneration influences the strain magnitude and stress distribution within the adjacent trabecular bone.Frontiers in bioengineering and biotechnology · 2024Article
- Automated segmentation and prediction of intervertebral disc morphology and uniaxial deformations from MRI.Osteoarthritis and cartilage open · 2023Article
- Digital image correlation techniques for motion analysis and biomechanical characterization of plants.Frontiers in plant science · 2023Review
- In vivo intervertebral disc mechanical deformation following a treadmill walking "stress test" is inversely related to T1rho relaxation time.Osteoarthritis and cartilage · 2023Article
- Quantifying internal intervertebral disc strains to assess nucleus replacement device designs: a digital volume correlation and ultra-high-resolution MRI study.Frontiers in bioengineering and biotechnology · 2023Article
- Sulforaphane Delays Intervertebral Disc Degeneration by Alleviating Endoplasmic Reticulum Stress in Nucleus Pulposus Cells via Activating Nrf-2/HO-1.Oxidative medicine and cellular longevity · 2023Article
- Regulated cell death: Implications for intervertebral disc degeneration and therapy.Journal of orthopaedic translation · 2022Review
- Design and clinical application of injectable hydrogels for musculoskeletal therapy.Bioengineering & translational medicine · 2022Review
- Digital volume correlation for the characterization of musculoskeletal tissues: Current challenges and future developments.Frontiers in bioengineering and biotechnology · 2022Review
- AnFrontiers in bioengineering and biotechnology · 2022Article
- Regulating the fate of stem cells for regenerating the intervertebral disc degeneration.World journal of stem cells · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intervertebral disc (IVD) plays a main role in absorbing and transmitting loads within the spinal column. Degeneration alters the structural integrity of the IVDs and causes pain, especially in the lumbar region. The objective of this study was to investigate non-invasively the effect of degeneration on human 3D lumbar IVD strains (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.