Evidence map›Paper›PMID 33552962›Full record

ArticleFrontiers in oncology2020

Risk Factors and Genetic Biomarkers of Multiple Primary Cancers in Esophageal Cancer Patients.

Pei-Wen Yang, Mei-Chun Lin, Pei-Ming Huang, Cheng-Ping Wang, Tseng-Cheng Chen, Chun-Nan Chen, Mong-Hsun Tsai, Jason Chia-Hsien Cheng, Eric Y Chuang, Min-Shu Hsieh and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Contribution ofPharmacogenomics and personalized medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Pei-Wen YangDepartment of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Mei-Chun LinDepartment of Surgery, National Taiwan University Cancer Center, Taipei, Taiwan.
Pei-Ming HuangDepartment of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Cheng-Ping WangDepartment of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Tseng-Cheng ChenDepartment of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Chun-Nan ChenDepartment of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Mong-Hsun TsaiGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
Jason Chia-Hsien ChengDepartment of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Eric Y ChuangGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
Min-Shu HsiehDepartment of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Pei-Jen LouDepartment of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Jang-Ming LeeDepartment of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
National Taiwan University Hospital · TWIndustrial Technology Research Institute · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal cancer (EC) is a deadly cancer that frequently develops multiple primary cancers (MPCs). However, the risk biomarkers of MPC in EC have hardly been investigated. We retrospectively enrolled 920 subjects with primary EC and analyzed the possible risk factors as well as MPC single-nucleotide polymorphisms (SNPs) from blood DNA. A total of 184 subjects (20.0%) were confirmed to have MPC, 59 (32.8%) had synchronous MPC, and 128 (69.6%) had head and neck cancer. Elderly EC patients have an increased risk of having gastrointestinal cancer (Odds ratio, OR[95% CI]=6.70 [1.49-30.19],

Indexed as

esophageal cancerhead and neck cancermultiple primary cancersecond primary cancersingle-nucleotide polymorphism

Identifiers

PMID33552962
PMCPMC7862767
OpenAlexW3125412174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.