Evidence map›Paper›PMID 33552906›Full record

ArticleMolecular genetics and metabolism reports2021

Transcriptome from opaque cornea of Fanconi anemia patient uncovers fibrosis and two connected players.

Bharesh K Chauhan, Anagha Medsinge, Hannah L Scanga, Charleen T Chu, Ken K Nischal

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Bharesh K ChauhanUPMC Eye Center, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Anagha MedsingeUPMC Eye Center, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Hannah L ScangaUPMC Eye Center, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Charleen T ChuDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Ken K NischalUPMC Eye Center, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
University of Pittsburgh · USChildren's Hospital of Pittsburgh · US

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ethan A Rossi · 1989 to 2026
$17.8M
Discovery and characterization of ocular regulatory elements through evolutionary analysisR01EY030546 · NEI · UNIVERSITY OF UTAH · PI CHIKINA, MARIA D, CLARK, NATHANIEL L · 2020 to 2024
$2.4M
NEI NIH HHS P30 EY008098NEI NIH HHS R01 EY030546
6 · The paper itself

Abstract

Congenital corneal opacities (CCO) are a group of blinding corneal disorders, where the underlying molecular mechanisms are poorly understood. Phenotyping through specialized imaging and histopathology analysis, together with assessment of key transcriptomic changes (including glycosaminoglycan metabolic enzymes) in cornea(s) with CCO from a case of Fanconi anemia is the approach taken in this study to identify causal mechanisms. Based on our findings, we propose a novel mechanism and two key players contributing to CCO.

Indexed as

Basement membrane disruptionCorneal opacityFibrosisGlycosaminoglycansTranscriptome analysis

Identifiers

PMID33552906
PMCPMC7846932
OpenAlexW3128783109

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.