ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021
Deep Learning Enables Superior Photoacoustic Imaging at Ultralow Laser Dosages.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Parallel multilayer photoacoustic microscopy of slide-free histology using a droplet-shaped UV beam.Science advances · 2026Article
- Photoacoustic imaging to optimize tumor delivery of human hemoglobin-derived oxygen carriers and subsequent photodynamic therapy.Biomedical optics express · 2026Article
- Linking Adjuvant Immune Stimulation to Spatiotemporal Dynamics via Cross-Scale Photoacoustic Microscopy.Chemical & biomedical imaging · 2026Article
- Physics-driven deep learning photoacoustic tomography.Fundamental research · 2026Article
- Advances in photoacoustic imaging reconstruction and quantitative analysis for biomedical applications.Visual computing for industry, biomedicine, and art · 2026Review
- Spectral-distortion-suppressed deep learning for fiber sensor photoacoustic microscopy.Photoacoustics · 2025Article
- High resolution photoacoustic vascular image reconstruction through the fast residual dense generative adversarial network.Photoacoustics · 2025Article
- Hybrid transformer-CNN network-driven optical-scanning undersampling for photoacoustic remote sensing microscopy.Photoacoustics · 2025Article
- Simultaneous head-mounted imaging of neural and hemodynamic activities at high spatiotemporal resolution in freely behaving mice.Science advances · 2025Article
- Quantitative volumetric photoacoustic assessment of vasoconstriction by topical corticosteroid application in mice skin.Photoacoustics · 2024Article
- Review on Photoacoustic Monitoring after Drug Delivery: From Label-Free Biomarkers to Pharmacokinetics Agents.Pharmaceutics · 2024Review
- TowardsFundamental research · 2024Review
- UPAMNet: A unified network with deep knowledge priors for photoacoustic microscopy.Photoacoustics · 2024Article
- Accelerating photoacoustic microscopy by reconstructing undersampled images using diffusion models.Scientific reports · 2024Article
- Perspectives on endoscopic functional photoacoustic microscopy.Applied physics letters · 2024Article
- U-Net enhanced real-time LED-based photoacoustic imaging.Journal of biophotonics · 2024Article
- Sounding out the dynamics: a concise review of high-speed photoacoustic microscopy.Journal of biomedical optics · 2024Review
- Enhanced resolution and sensitivity acoustic-resolution photoacoustic microscopy with semi/unsupervised GANs.Scientific reports · 2023Article
- Super-Low-Dose Functional and Molecular Photoacoustic Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Homogeneous-resolution photoacoustic microscopy for ultrawide field-of-view neurovascular imaging in Alzheimer's disease.Photoacoustics · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical-resolution photoacoustic microscopy (OR-PAM) is an excellent modality for in vivo biomedical imaging as it noninvasively provides high-resolution morphologic and functional information without the need for exogenous contrast agents. However, the high excitation laser dosage, limited imaging speed, and imperfect image quality still hinder the use of OR-PAM in clinical applications. The laser dosage, imaging speed, and image quality are mutually restrained by each other, and thus far, no methods have been proposed to resolve this challenge. Here, a deep learning method called the multitask residual dense network is proposed to overcome this challenge. This method utilizes an innovative strategy of integrating multisupervised learning, dual-channel sample collection, and a reasonable weight distribution. The proposed deep learning method is combined with an application-targeted modified OR-PAM system. Superior images under ultralow laser dosage (32-fold reduced dosage) are obtained for the first time in this study. Using this new technique, a high-quality, high-speed OR-PAM system that meets clinical requirements is now conceivable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.