ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021
Controllable Cell Deformation Using Acoustic Streaming for Membrane Permeability Modulation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 65 citations in OpenAlex.
- Noninvasive biophysical modulations of Piezo ion channels.Microsystems & nanoengineering · 2026Review
- Enhancing cancer therapyLab on a chip · 2025Article
- Remote biofilm dislodgment using focused acoustic vortex.Ultrasonics sonochemistry · 2025Article
- Hypersonic levitation and spinning: paving the way for enhanced single-cell analysis via contactless tissue dissociation.Communications engineering · 2025Article
- An acoustofluidic embedding platform for rapid multiphase microparticle injection.Nature communications · 2025Article
- Recent advances in microscale techniques for red blood cells manipulation.Biomicrofluidics · 2025Review
- Flexible surface acoustic wave technology for enhancing transdermal drug delivery.Drug delivery and translational research · 2025Article
- Spatial regulation of hydrogel polymerization reaction using ultrasound-driven streaming vortex.Ultrasonics sonochemistry · 2024Article
- Acoustofluidic Actuation of Living Cells.Micromachines · 2024Review
- Advancements in strategies for overcoming the blood-brain barrier to deliver brain-targeted drugs.Frontiers in aging neuroscience · 2024Review
- Open source board based acoustofluidic transwells for reversible disruption of the blood-brain barrier for therapeutic delivery.Biomaterials research · 2023Article
- Basic Principles of RNA Interference: Nucleic Acid Types and In Vitro Intracellular Delivery Methods.Micromachines · 2023Review
- The image-based ultrasonic cell shaking test.PloS one · 2023Article
- Acoustic-propelled micro/nanomotors and nanoparticles for biomedical research, diagnosis, and therapeutic applications.Frontiers in bioengineering and biotechnology · 2023Review
- Microfluidic technologies for cell deformability cytometry.Smart medicine · 2022Review
- Light-driven high-precision cell adhesion kinetics.Light, science & applications · 2022Article
- Self-adaptive virtual microchannel for continuous enrichment and separation of nanoparticles.Science advances · 2022Article
- Sonoporation: Past, Present, and Future.Advanced materials technologies · 2022Article
- Controllable Cell Deformation Using Acoustic Streaming for Membrane Permeability Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrodynamic force loading platforms for controllable cell mechanical deformation play an essential role in modern cell technologies. Current systems require assistance from specific microstructures thus limiting the controllability and flexibility in cell shape modulation, and studies on real-time 3D cell morphology analysis are still absent. This article presents a novel platform based on acoustic streaming generated from a gigahertz device for cell shape control and real-time cell deformation analysis. Details in cell deformation and the restoration process are thoroughly studied on the platform, and cell behavior control at the microscale is successfully achieved by tuning the treating time, intensity, and wave form of the streaming. The application of this platform in cell membrane permeability modulation and analysis is also exploited. Based on the membrane reorganization during cell deformation, the effects of deformation extent and deformation patterns on membrane permeability to micro- and macromolecules are revealed. This technology has shown its unique superiorities in cell mechanical manipulation such as high flexibility, high accuracy, and pure fluid force operation, indicating its promising prospect as a reliable tool for cell property study and drug therapy development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.