Evidence map›Paper›PMID 33552818›Full record

ArticlePlastic and reconstructive surgery. Global open2021

Botulinum Toxin Type A as a Tool for Correcting Capsular Contracture after Reconstructive Breast Surgery.

Aziz D Zikiryakhodzhaev, Galina S Alekseeva, Igor V Reshetov, Marianna V Starkova, Eric K Saribekyan, Fedor N Usov, Maria Yu Vlasova

Open access · goldAbstract readCase Reports
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Aziz D ZikiryakhodzhaevDepartment of Oncology and Reconstuctive Plastic Surgery of Breast and Skin, P.A. Hertsen Moscow Oncology Research Center, Moscow, Russian Federation.
Galina S AlekseevaDepartment of Oncology and Reconstuctive Plastic Surgery of Breast and Skin, P.A. Hertsen Moscow Oncology Research Center, Moscow, Russian Federation.
Igor V ReshetovFederal State Autonomous Educational Institution for Higher Education, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), Moscow, Russian Federation.
Marianna V StarkovaDepartment of Oncology and Reconstuctive Plastic Surgery of Breast and Skin, P.A. Hertsen Moscow Oncology Research Center, Moscow, Russian Federation.
Eric K SaribekyanDepartment of Oncology and Reconstuctive Plastic Surgery of Breast and Skin, P.A. Hertsen Moscow Oncology Research Center, Moscow, Russian Federation.
Fedor N UsovDepartment of Oncology and Reconstuctive Plastic Surgery of Breast and Skin, P.A. Hertsen Moscow Oncology Research Center, Moscow, Russian Federation.
Maria Yu VlasovaDepartment of Oncology and Reconstuctive Plastic Surgery of Breast and Skin, P.A. Hertsen Moscow Oncology Research Center, Moscow, Russian Federation.
P.A. Hertzen Moscow Oncology Research Institute · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Capsular contracture is one of the most common complications after breast reconstruction. Surgical treatment is the main option for capsular contracture correction and includes capsulotomy, capsulectomy, and removal/replacement of the affected implant. However, the surgical trauma from reoperation, along with reduced quality of life, in patients with clinically significant capsular contracture has prompted a search for alternative treatment options. The use of the botulinum toxin type A in the treatment of neurological diseases and of keloid scars in aesthetic practice nudged the idea of using the same toxin for the correction of capsular contractures in breast cancer patients. Botulinum toxin type A injection is an easy procedure requiring no anesthesia or inpatient care. The treatment has few side effects. In addition, the injection does not cause sensory loss or dysesthesia. We described a clinical case of the capsular contracture correction using incobotulinumtoxin A. Capsular contracture IV developed 4 months post surgery after long-term lymphorrhea. Radiation therapy was not performed. According to the internal protocol, the patient was advised to undergo incobotulinumtoxin A treatment instead of surgery. Within 1 week after the second injection, all symptoms decreased-specifically, the general shape of the reconstructed breast. Also, the pain syndrome disappeared.

Identifiers

PMID33552818
PMCPMC7861963
OpenAlexW3126094218

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.