Evidence map›Paper›PMID 33552711›Full record

ArticlePeerJ2021

Gender-related disparities in the frequencies of PD-1 and PD-L1 positive peripheral blood T and B lymphocytes in patients with alcohol-related liver disease: a single center pilot study.

Beata Kasztelan-Szczerbinska, Katarzyna Adamczyk, Agata Surdacka, Jacek Rolinski, Agata Michalak, Agnieszka Bojarska-Junak, Mariusz Szczerbinski, Halina Cichoz-Lach

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Immune cells in alcohol-related liver disease.Liver research (Beijing, China) · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Beata Kasztelan-SzczerbinskaDepartment of Gastroenterology with Endoscopy Unit, Medical University of Lublin, Poland, Lublin, Poland.
Katarzyna AdamczykDepartment of Gastroenterology with Endoscopy Unit, Medical University of Lublin, Poland, Lublin, Poland.
Agata SurdackaDepartment of Clinical Immunology, Medical University of Lublin, Poland, Lublin, Poland.
Jacek RolinskiDepartment of Clinical Immunology, Medical University of Lublin, Poland, Lublin, Poland.
Agata MichalakDepartment of Gastroenterology with Endoscopy Unit, Medical University of Lublin, Poland, Lublin, Poland.
Agnieszka Bojarska-JunakDepartment of Clinical Immunology, Medical University of Lublin, Poland, Lublin, Poland.
Mariusz SzczerbinskiDepartment of Gastroenterology with Endoscopy Unit, Public, Academic Hospital No 4, Lublin, Poland.
Halina Cichoz-LachDepartment of Gastroenterology with Endoscopy Unit, Medical University of Lublin, Poland, Lublin, Poland.
Medical University of Lublin · PL1 Military Clinical Hospital with Outpatient Clinic · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExposure to excessive alcohol consumption dysregulates immune signaling. The programed cell death 1 (PD-1) receptor and its ligand PD-L1 play a critical role in the protection against immune-mediated tissue damage. The aim of our study was evaluation of the PD-1/PDL-1 expression on peripheral T and B lymphocytes, its correlation with markers of inflammation and the severity of liver dysfunction in the course of alcohol-related liver disease (ALD). MATERIAL AND

methodsFifty-six inpatients with ALD (38 males, 18 females, aged 49.23 ± 10.66) were prospectively enrolled and assigned to subgroups based on their: (1) gender, (2) severity of liver dysfunction (Child-Pugh, MELD scores, mDF), (3) presence of ALD complications, and followed for 30 days. Twenty-five age- and gender-matched healthy volunteers served as the control group. Flow cytometric analysis of the PD-1/PD-L1 expression on peripheral lymphocyte subsets were performed.

resultsGeneral frequencies of PD-1/PD-L1 positive T and B subsets did not differ between the ALD and control group. When patients were analyzed based on their gender, significantly higher frequencies of PD1/PD-L1 positive B cells in ALD females compared to controls were observed. ALD females presented with significantly higher frequencies of PD-1+ and PD-L1+ B cells, as well as PD-L1+ all T cell subsets in comparison with ALD males. The same gender pattern of the PD-1/PDL1 expression was found in the subgroups with mDF > 32 and MELD > 20. No correlations of PD-1+ and PD-L1+ lymphocyte percentages with mDF, CTP and MELD scores, nor with complications of ALD were observed. Significant correlations of PD-L1 positive B cell frequencies with conventional markers of inflammation were found.

conclusionsGender-related differences in the frequencies of PD-1/PD-L1 positive T and B cells were observed in patients with ALD. Upregulation of PD-1+/PD-L1+ lymphocytes paralleled both the severity of alcoholic hepatitis and liver dysfunction in ALD females.

Indexed as

Alcohol-related liver diseaseB lymphocytesProgrammed cell death-1 receptorProgrammed cell death receptor ligand 1T lymphocytes

Identifiers

PMID33552711
PMCPMC7825365
OpenAlexW3121830315

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.