Evidence map›Paper›PMID 33552562›Full record

ArticleGames2018

Fractionated follow-up chemotherapy delays the onset of resistance in bone metastatic prostate cancer.

Pranav I Warman, Artem Kaznatcheev, Arturo Araujo, Conor C Lynch, David Basanta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Games, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Modeling cancer's ecological and evolutionary dynamics.Medical oncology (Northwood, London, England) · 2023
    Article
  3. Article
  4. Review
  5. Review
  6. Bone metastasis treatment modeling via optimal control.Journal of mathematical biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Pranav I WarmanDuke University, Durham, NC, USA.
Artem KaznatcheevDepartment of Computer Science, University of Oxford, Oxford, UK.
Arturo AraujoIntegrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Conor C LynchDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
David BasantaIntegrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Moffitt Cancer Center · USCleveland Clinic · USDuke University · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Multiscale Modeling of Bone Environment Responses to Metastatic Prostate CancerU01CA202958 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI BASANTA GUTIERREZ, DAVID, LYNCH, CONOR C · 2016 to 2020
$3.3M
NCI NIH HHS P30 CA076292NCI NIH HHS U01 CA202958
6 · The paper itself

Abstract

Prostate cancer to bone metastases are almost always lethal. This results from the ability of metastatic prostate cancer cells to co-opt bone remodeling leading to what is known as the

Indexed as

chemotherapyevolutionary game theoryheterogeneityprostate cancer bone metastasisresistance

Identifiers

PMID33552562
PMCPMC7864372
OpenAlexW2794823324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.