ReviewPaediatrics & child health2021
Guidelines for surfactant replacement therapy in neonates.
Review in Paediatrics & child health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 6 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Overview of the Effectiveness of Different Surfactant Administration Methods: An Umbrella Review of Meta-Analyses.Pediatric pulmonology · 2026Pooled it
- Risk factors for pulmonary hemorrhage of very low birth weight infants: a meta-analysis.Italian journal of pediatrics · 2026Pooled it
- The Care of Preterm and Term Newborns with Respiratory Conditions: A Systematic Synthesis of Evidence from Low- and Middle-Income Countries.Neonatology · 2025Pooled it
- Thresholds for surfactant use in preterm neonates: a network meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2023Pooled it
- Surfactant delivery via thin catheter in preterm infants: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Use of budesonide associated with a pulmonary surfactant to prevent bronchopulmonary dysplasia in premature newborns - A systematic review.Jornal de pediatriaPooled it
- A novel double-lumen tracheal tube-assisted InSurE versus LISA in preterm infants with RDS: a multicenter randomized trial.Frontiers in pediatrics · 2026Trial
- Higher (40%) versus lower (30%) FiOEuropean journal of pediatrics · 2025Trial
- A Comparison of the Effect of Beractant (Beracsurf) and Proctant Alpha (Curosurf) in Neonatal Respiratory Distress: A Randomized Controlled Trial.Iranian journal of medical sciences · 2025Trial
- High vs low CPAP strategy with aerosolized calfactant in preterm infants with respiratory distress syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- Response to aerosolized calfactant in infants with respiratory distress syndrome; a post-hoc analysis of AERO-02 trial.Journal of perinatology : official journal of the California Perinatal Association · 2023Trial
- Biophysical rationale and emerging clinical perspectives of surfactants in thoracic surgery: a translational review.Langenbeck's archives of surgery · 2026Review
- Self-adaptive and configurable transfer printing of flexible electronics via rheology of liquid foam.Science advances · 2026Article
- Pulmonary Surfactant Treatment for Preterm Infants With Respiratory Distress Syndrome: A Nationwide Survey.The clinical respiratory journal · 2026Article
- Equity and Respect in Maternal and Infant Healthcare-A Report From the 2025 Venice Forum.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Surfactant administration in late preterm and term neonates: is LISA ready for routine use?European journal of pediatrics · 2026Review
- Lung Ultrasound-Guided Surfactant Therapy in Neonatal Pneumothorax and Pulmonary Hemorrhage: Pathophysiology, Diagnostic Ultrasonography, and Emerging Clinical Approaches.Children (Basel, Switzerland) · 2026Review
- Convergence and Reducibility as Transferability Filters in Biomimetic Design.Journal of functional biomaterials · 2026Review
- Surfactant retreatment in very preterm infants with respiratory distress syndrome: an observational cohort study.Translational pediatrics · 2026Article
- Surfactant use and outcomes in middle-income versus high-income countries.Journal of tropical pediatrics · 2026Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surfactant replacement therapy (SRT) plays a pivotal role in the management of neonates with respiratory distress syndrome (RDS) because it improves survival and reduces respiratory morbidities. With the increasing use of noninvasive ventilation as the primary mode of respiratory support for preterm infants at delivery, prophylactic surfactant is no longer beneficial. For infants with worsening RDS, early rescue surfactant should be provided. While the strategy to intubate, give surfactant, and extubate (INSURE) has been widely accepted in clinical practice, newer methods of noninvasive surfactant administration, using thin catheter, laryngeal mask airway, or nebulization, are being adopted or investigated. Use of SRT as an adjunct for conditions other than RDS, such as meconium aspiration syndrome, may be effective based on limited evidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.