Evidence map›Paper›PMID 33552310›Full record

ArticleJournal of pharmaceutical innovation2022

Analysis of the COVID-19 Vaccine Development Process: an Exploratory Study of Accelerating Factors and Innovative Environments.

Hugo Garcia Tonioli Defendi, Luciana da Silva Madeira, Suzana Borschiver

Open access · bronzeAbstract read
In one paragraph

Article in Journal of pharmaceutical innovation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  8. Article
  9. Vaccine Innovation Meta-Model for Pandemic Contexts.Journal of pharmaceutical innovation · 2023
    Article
  10. Public Health Management of the COVID-19 Pandemic in Australia: The Role of the Morrison Government.International journal of environmental research and public health · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hugo Garcia Tonioli DefendiCenter for Industrial and Technological Studies (NEITEC), Universidade Federal Do Rio de Janeiro, Rio de Janeiro, RJ Brazil.ORCID 0000-0002-4555-1784
Luciana da Silva MadeiraMacromolecule Laboratory, Fundação Oswaldo Cruz/Bio-Manguinhos, Rio de Janeiro, RJ Brazil.ORCID 0000-0002-7050-3207
Suzana BorschiverCenter for Industrial and Technological Studies (NEITEC), Universidade Federal Do Rio de Janeiro, Rio de Janeiro, RJ Brazil.ORCID 0000-0002-9551-7795
Universidade Federal do Rio de Janeiro · BRFundação Oswaldo Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The pace of the COVID-19 vaccine development process is unprecedented and is challenging the traditional paradigm of vaccinology science. The main pressure comes from the pandemic situation, but what makes it possible is a complex set of factors and innovative environments built along the times, which this manuscript aims to study. Methods: Through an exploratory study within the scope of innovation management, the present manuscript aims to identify and explore factors that are promoting this accelerated development scenario. The method comprises the monitoring of the strategies adopted by the developers and other stakeholders, as regulatory and humanitarian agencies, specific mechanisms from governments and non-governments bodies, and the background technology that has paved this pathway. Results: Technology-based and R&D strategy factors are the two main factors identified and explored herein. The breakthrough in the field of biotechnology and molecular biology is considered the main base-science that enables the rapid development of new vaccines. Additionally, new technological platforms can also be pointed out. Relating to R&D strategies, the parallelism of phases and adaptive clinical trials in consonance with regulatory agencies are the most relevant. Conclusions: The need to rapidly develop a vaccine against COVID-19 occurs at a time of great excitement in basic scientific understanding, as well as strategies learned in the past by industry and optimization of regulatory pathways. It is expected that these factors, arising from the global emergency, may redirect the R&D processes for new drugs, especially in times of pandemic.

Indexed as

COVID-19Innovation managementProduct development processVaccine

Identifiers

PMID33552310
PMCPMC7851325
OpenAlexW3128262448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.