Evidence map›Paper›PMID 33552087›Full record

ReviewFrontiers in immunology2020

The New Frontier of Host-Directed Therapies for

Nathan P Crilly, Samuel K Ayeh, Petros C Karakousis

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. The Association between Dyslipidemia and Pulmonary Diseases.Journal of atherosclerosis and thrombosis · 2024
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Metformin improvesFrontiers in immunology · 2024
    Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nathan P CrillyDepartment of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Samuel K AyehDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Petros C KarakousisDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
Statins as Adjunctive, Host-Directed Therapy for TBUH3AI122309 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARAKOUSIS, PETROS C · 2017 to 2019
$4.3M
Mentoring in Immunometabolic Dysregulation in TB and TB/HIVK24AI143447 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARAKOUSIS, PETROS C · 2019 to 2024
$956k
NIAID NIH HHS K24 AI143447NIAID NIH HHS UH3 AI122309NIH HHS T32 OD011089
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Lung DiseasesMycobacterium avium-intracellulare InfectionPrecision MedicineAnti-Bacterial AgentsHumansImmunologic FactorsMycobacterium avium ComplexAnti-Bacterial AgentsImmunologic Factorsdrug repurposinghost-directed therapyMycobacterium avium complexMycobacterium tuberculosisnontuberculous mycobacteria (NTM)

Identifiers

PMID33552087
PMCPMC7862709
OpenAlexW3121198347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.