Evidence map›Paper›PMID 33552084›Full record

ArticleFrontiers in immunology2020

C-Reactive Protein-Based Strategy to Reduce Antibiotic Dosing for the Treatment of Pneumococcal Infection.

Donald N Ngwa, Sanjay K Singh, Alok Agrawal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Donald N NgwaDepartment of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
Sanjay K SinghDepartment of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
Alok AgrawalDepartment of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
East Tennessee State University · US

Funding

C-reactive protein in rheumatoid arthritisR01AR068787 · NIAMS · EAST TENNESSEE STATE UNIVERSITY · PI AGRAWAL, ALOK · 2015 to 2019
$2.7M
Complement-mediated anti-pneumococcal functions of C-reactive proteinR01AI151561 · NIAID · EAST TENNESSEE STATE UNIVERSITY · PI SINGH, SANJAY KUMAR · 2020 to 2024
$1.9M
NIAID NIH HHS R01 AI151561NIAMS NIH HHS R01 AR068787
6 · The paper itself

Abstract

C-reactive protein (CRP) is a component of innate immunity. The concentration of CRP in serum increases in microbial infections including

Indexed as

Amino Acid SubstitutionAnimalsAnti-Bacterial AgentsBacteremiaClarithromycinC-Reactive ProteinDrug Evaluation, PreclinicalDrug Therapy, CombinationImmunity, InnateMaleMiceMice, Inbred C57BLMutagenesis, Site-DirectedMutation, MissensePneumococcal InfectionsRecombinant ProteinsAnti-Bacterial AgentsClarithromycinC-Reactive ProteinRecombinant Proteinsclarithromycincombination therapyC-reactive proteinpneumococcal infectionStreptococcus pneumoniae

Identifiers

PMID33552084
PMCPMC7854908
OpenAlexW3125231591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.