Evidence map›Paper›PMID 33552057›Full record

ArticleFrontiers in immunology2020

Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy.

Ahmed M Abu El-Asrar, Mohd Imtiaz Nawaz, Ajmal Ahmad, Alexandra De Zutter, Mohammad Mairaj Siddiquei, Marfa Blanter, Eef Allegaert, Priscilla W Gikandi, Gert De Hertogh, Jo Van Damme and 2 more

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ahmed M Abu El-AsrarDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Mohd Imtiaz NawazDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ajmal AhmadDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Alexandra De ZutterLaboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
Mohammad Mairaj SiddiqueiDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Marfa BlanterLaboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
Eef AllegaertLaboratory of Histochemistry and Cytochemistry, University of Leuven, Leuven, Belgium.
Priscilla W GikandiDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Gert De HertoghLaboratory of Histochemistry and Cytochemistry, University of Leuven, Leuven, Belgium.
Jo Van DammeLaboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
Ghislain OpdenakkerLaboratory of Immunobiology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
Sofie StruyfLaboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
King Saud University · SAKU Leuven · BERega Institute for Medical Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transmembrane chemokine pathways CXCL16/CXCR6 and CX3CL1/CX3CR1 are strongly implicated in inflammation and angiogenesis. We investigated the involvement of these chemokine pathways and their processing metalloproteinases ADAM10 and ADAM17 in the pathophysiology of proliferative diabetic retinopathy (PDR). Vitreous samples from 32 PDR and 24 non-diabetic patients, epiretinal membranes from 18 patients with PDR, rat retinas, human retinal Müller glial cells and human retinal microvascular endothelial cells (HRMECs) were studied by enzyme-linked immunosorbent assay, immunohistochemistry and Western blot analysis.

Indexed as

ADAM10 ProteinADAM17 ProteinAmyloid Precursor Protein SecretasesAnimalsChemokine CX3CL1Chemokine CXCL16CX3C Chemokine Receptor 1Diabetic RetinopathyHumansMaleMembrane ProteinsRatsADAM10 ProteinADAM10 protein, humanADAM10 protein, ratADAM17 ProteinADAM17 protein, humanAdam17 protein, ratAmyloid Precursor Protein SecretasesChemokine CX3CL1Chemokine CXCL16CX3C Chemokine Receptor 1CX3CL1 protein, humanCx3cl1 protein, ratCX3CR1 protein, humanCX3CR1 protein, ratCXCL16 protein, humanMembrane ProteinsADAM10ADAM17chemokinesCX3CL1CXCL16metalloproteinasesproliferative diabetic retinopathy

Identifiers

PMID33552057
PMCPMC7854927
OpenAlexW3121155413

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.