Evidence map›Paper›PMID 33551954›Full record

ArticleFrontiers in neurology2020

Early Stages of Alzheimer's Disease: Evolving the Care Team for Optimal Patient Management.

James E Galvin, Paul Aisen, Jessica B Langbaum, Eric Rodriguez, Marwan Sabbagh, Richard Stefanacci, Robert A Stern, Elizabeth A Vassey, Arno de Wilde, Neva West and 1 more

Abstract read
In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Review
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  9. Article
  10. Article
  11. Detection and Diagnosis of Early Symptomatic Alzheimer's Disease in Primary Care.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024
    Article
  12. Article
  13. Review
  14. 2024 Alzheimer's disease facts and figures.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

James E GalvinComprehensive Center for Brain Health, University of Miami Miller School of Medicine, Miami, FL, United States.
Paul AisenUSC Alzheimer's Research Institute, San Diego, CA, United States.
Jessica B LangbaumBanner Alzheimer's Institute, Phoenix, AZ, United States.
Eric RodriguezUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Marwan SabbaghCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States.
Richard StefanacciThomas Jefferson University, Philadelphia, PA, United States.
Robert A SternBoston University Alzheimer's Disease Center, Boston University School of Medicine, Boston, MA, United States.
Elizabeth A VasseyBoston University Alzheimer's Disease Center, Boston University School of Medicine, Boston, MA, United States.
Arno de WildeAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Neva WestBiogen, Cambridge, MA, United States.
Ivana RubinoBiogen, Cambridge, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive, neurodegenerative disease that creates complex challenges and a significant burden for patients and caregivers. Although underlying pathological changes due to AD may be detected in research studies decades prior to symptom onset, many patients in the early stages of AD remain undiagnosed in clinical practice. Increasing evidence points to the importance of an early and accurate AD diagnosis to optimize outcomes for patients and their families, yet many barriers remain along the diagnostic journey. Through a series of international working group meetings, a diverse group of experts contributed their perspectives to create a blueprint for a patient-centered diagnostic journey for individuals in the early stages of AD and an evolving, transdisciplinary care team. Here, we discuss key learnings, implications, and recommendations.

Indexed as

Alzheimer's diseasedementiadiagnosisearly detectionmild cognitive impairment

Identifiers

PMID33551954
PMCPMC7863984

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.