Evidence map›Paper›PMID 33551837›Full record

ArticleFrontiers in physiology2020

Chronic Cranial Windows for Long Term Multimodal Neurovascular Imaging in Mice.

Kıvılcım Kılıç, Michèle Desjardins, Jianbo Tang, Martin Thunemann, Smrithi Sunil, Şefik Evren Erdener, Dmitry D Postnov, David A Boas, Anna Devor

Abstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Prolonged systemic inflammation worsens impairments to astrocyte CaAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
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  5. Article
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  9. Prolonged systemic inflammation worsens impairments to astrocyte CabioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. A clinically relevant model and method to study necrosis as a driving force in glioma restructuring and progression.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. WidefieldNeurophotonics · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Two-Photon Intravital Microscopy of Glioblastoma in a Murine Model.Journal of visualized experiments : JoVE · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kıvılcım KılıçBiomedical Engineering, Boston University, Boston, MA, United States.
Michèle DesjardinsCentre de recherche du CHU de Québec, Université Laval, Quebec City, QC, Canada.
Jianbo TangBiomedical Engineering, Boston University, Boston, MA, United States.
Martin ThunemannBiomedical Engineering, Boston University, Boston, MA, United States.
Smrithi SunilBiomedical Engineering, Boston University, Boston, MA, United States.
Şefik Evren ErdenerBiomedical Engineering, Boston University, Boston, MA, United States.
Dmitry D PostnovBiomedical Engineering, Boston University, Boston, MA, United States.
David A BoasBiomedical Engineering, Boston University, Boston, MA, United States.
Anna DevorBiomedical Engineering, Boston University, Boston, MA, United States.

Funding

MICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGINGR01MH111359 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M, DEVOR, ANNA · 2016 to 2020
$5.6M
The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneityR01NS108472 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BOAS, DAVID A, SCHAFFER, CHRIS B · 2018 to 2022
$3.2M
Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular ChangesR01EB021018 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 2015 to 2018
$2.9M
Neuronal, glial and BOLD fMRI signals: From BOLD to 2-photon microscopyR01NS057198 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEVOR, ANNA · 2009 to 2017
$2.6M
Effects of intrinsic and drug-induced neuromodulation on functional brain imagingR01DA050159 · NIDA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI DEVOR, ANNA · 2020 to 2024
$1.9M
Transparent neural interface for in vivo interrogation of human organoidsR21EY030727 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEVOR, ANNA · 2019 to 2019
$456k
Dual-modal ultrasound velocimetry and photoacoustic oximetry of entire rodent brain for Alzheimer's Disease studyK99AG063762 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI TANG, JIANBO · 2020 to 2020
$115k
NEI NIH HHS R21 EY030727NIA NIH HHS K99 AG063762NIBIB NIH HHS R01 EB021018NIDA NIH HHS R01 DA050159NIMH NIH HHS R01 MH111359NINDS NIH HHS R01 NS057198NINDS NIH HHS R01 NS108472
6 · The paper itself

Abstract

Chronic cranial windows allow for longitudinal brain imaging experiments in awake, behaving mice. Different imaging technologies have their unique advantages and combining multiple imaging modalities offers measurements of a wide spectrum of neuronal, glial, vascular, and metabolic parameters needed for comprehensive investigation of physiological and pathophysiological mechanisms. Here, we detail a suite of surgical techniques for installation of different cranial windows targeted for specific imaging technologies and their combination. Following these techniques and practices will yield higher experimental success and reproducibility of results.

Indexed as

awakechronicimagingmicemultimodalneuralvascular

Identifiers

PMID33551837
PMCPMC7862556

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.