Evidence map›Paper›PMID 33551571›Full record

ArticleSensors and actuators. B, Chemical2021

Sodium-Sensitive Contact Lens for Diagnostics of Ocular Pathologies.

Ramachandram Badugu, Henryk Szmacinski, E Albert Reece, Bennie H Jeng, Joseph R Lakowicz

Abstract read
In one paragraph

Article in Sensors and actuators. B, Chemical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ramachandram BaduguCenter for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology University of Maryland School of Medicine, 725 West Lombard St., Baltimore, MD 21201, USA.
Henryk SzmacinskiCenter for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology University of Maryland School of Medicine, 725 West Lombard St., Baltimore, MD 21201, USA.
E Albert ReeceDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD 21201, USA.
Bennie H JengDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, 419 W. Redwood Street, Baltimore, Md 21201, USA.
Joseph R LakowiczCenter for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology University of Maryland School of Medicine, 725 West Lombard St., Baltimore, MD 21201, USA.

Funding

Coupled Emission Microscopy for the BiosciencesR01GM125976 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2018 to 2021
$1.8M
Diffusion-Enhanced Lanthanide Nanoparticle FRET AssaysR21GM107986 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2014 to 2016
$568k
Fluorescence Lifetime Imaging Microscopy (FLIM)S10RR026370 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2010 to 2010
$474k
Plasmon-coupled Fluorescence Correlation Spectroscopy in NanoholesR21GM129561 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2018 to 2019
$413k
Multi-User Time-Resolved Fluorescence SpectrometerS10OD019975 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2015 to 2015
$243k
NCRR NIH HHS S10 RR026370NIGMS NIH HHS R01 GM125976NIGMS NIH HHS R21 GM107986NIGMS NIH HHS R21 GM129561NIH HHS S10 OD019975
6 · The paper itself

Abstract

The ability to measure all the electrolyte concentrations in tears would be valuable in ophthalmology for research and diagnosis of dry eye disease (DED) and other ocular pathologies. However, tear samples are difficult to collect and analyze because the total volume is small and the chemical composition changes rapidly. Measurements of electrolytes in tears is challenging because typical clinical assays for proteins and other biomarkers cannot be used to detect ion concentrations tears. Here, we report the contact lens which is sensitive to sodium ion (Na

Indexed as

Contact LensesDry Eye DiseaseElectrolytes in TearsFluorescence SensingSodium GreenSodium IonsTear Composition

Identifiers

PMID33551571
PMCPMC7861470

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.