ArticleEndocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists2021
Sick Euthyroid Syndrome on Presentation of Patients With COVID-19: A Potential Marker for Disease Severity.
Article in Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Predictive factors of permanent hypothyroidism after subacute thyroiditis: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review.Frontiers in endocrinology · 2024Pooled it
- Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Association of thyroid dysfunction and COVID-19: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- The Association Between COVID-19 and Thyroxine Levels: A Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Relation of Serum Copper Status to Survival in COVID-19.Nutrients · 2021Trial
- The Relationship Between Pituitary Axis Hormones and All-Cause Mortality in Hospitalized Patients with Chronic Diseases: A Prospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Frequency and Impact of Thyroid Hormone Abnormalities in COVID-19: An Observational Study at the Peak of the Pandemic.Clinical medicine insights. Endocrinology and diabetes · 2026Article
- Non-thyroidal illness syndrome subtypes and mortality in sepsis: associations with thyroid autoantibodies.Frontiers in endocrinology · 2026Article
- Critical illness-implications of non-thyroidal illness syndrome and thyroxine therapy.World journal of critical care medicine · 2025Review
- Euthyroid Sick Syndrome as an Index of Prognosis in Severe COVID-19 Disease.Medicina (Kaunas, Lithuania) · 2025Article
- Association of COVID-19 with thyroid dysfunction and autoimmune thyroid disease: A retrospective cohort study.Journal of translational autoimmunity · 2024Article
- Euthyroid sick syndrome predicts the risk of ischemic stroke-associated pneumonia in the acute stage of ischemic stroke: a nested case-control study.Frontiers in endocrinology · 2024Article
- Determining the frequency of thyroid involvement in chest CT scans of COVID-19 patients and its correlation with the severity of lung involvement and survival of patients in 2020.Frontiers in endocrinology · 2024Article
- Clinical presentation and prognosis of COVID-19 in older adults with hypothyroidism: data from the GeroCovid observational study.Journal of endocrinological investigation · 2023Observational
- Long-term outcome of thyroid abnormalities in patients with severe Covid-19.European thyroid journal · 2023Article
- The Influence of SARS-CoV-2 Infection on the Thyroid Gland.Biomedicines · 2023Review
- Thyroid hormones and platelet activation in COVID-19 patients.Journal of endocrinological investigation · 2023Article
- Transient low T3 syndrome in patients with COVID-19: a new window for prediction of disease severity.Frontiers in endocrinology · 2023Article
- Understanding anti-TNF treatment failure: does serum triiodothyronine-to-thyroxine (T3/T4) ratio predict therapeutic outcome to anti-TNF therapies in biologic-naïve patients with active luminal Crohn's disease?Alimentary pharmacology & therapeutics · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrecise risk stratification and triage of coronavirus disease 2019 (COVID-19) patients are essential in the setting of an overwhelming pandemic burden. Clinical observation has shown a somewhat high prevalence of sick euthyroid syndrome among patients with COVID-19. This study aimed to evaluate the predictive value of free triiodothyronine (FT3) at the clinical presentation of COVID-19 for disease severity and death.
methodsThis retrospective cohort study was based on electronic medical records. The study was conducted at Sheba Medical Centre, a tertiary hospital where several acute and chronic wards have been dedicated to the treatment of patients with COVID-19. The primary outcome measure was death during hospitalization; secondary outcomes included hospitalization in intensive care, mechanical ventilation, and length of hospitalization.
resultsOf a total of 577 polymerase chain reaction-positive patients with COVID-19 hospitalized between February 27 and July 30, 2020, 90 had at least 1 measurement of thyroid-stimulating hormone, free thyroxine, and FT3 within 3 days of presentation. After applying strict exclusion criteria, 54 patients were included in the study. Patients in the lowest tertile of FT3 had significantly higher rates of mortality (40%, 5.9%, and 5.9%, P = .008), mechanical ventilation (45%, 29.4%, and 0.0%; P = .007) and intensive care unit admission (55%, 29.4%, and 5.9%, P = .006). In multivariate analyses adjusted for age, Charlson comorbidity index, creatinine, albumin, and white blood cell count. FT3 remained a significant independent predictor of death.
conclusionFT3 levels can serve as a prognostic tool for disease severity in the early presentation of COVID-19.
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