Evidence map›Paper›PMID 33551175›Full record

ArticleLung cancer (Amsterdam, Netherlands)2021

Examination of factors associated with lymph node metastases in lung carcinoids: Results from a single institution retrospective cohort study.

Mythili P Pathipati, Thomas K Yohannan, Lu Tian, Kathleen Hornbacker, Jalen A Benson, Gerald J Berry, Natalie S Lui, Pamela L Kunz, Sukhmani K Padda

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung cancer (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Mythili P PathipatiStanford University School of Medicine, Stanford Cancer Institute, Department of Medicine, Division of Oncology, 875 Blake Wilbur, Stanford, CA, 94305, USA; Massachusetts General Hospital, Division of Internal Medicine, 55 Fruit Street, Boston, MA, 02114, USA.
Thomas K YohannanStanford University School of Medicine, Department of Radiology, 300 Pasteur Dr, Palo Alto, CA, 94304, USA; Kaiser Permanente Richmond Medical Center, Department of Nuclear Medicine, 901 Nevin Avenue, Richmond, CA, 94801, USA.
Lu TianStanford University School of Medicine, Department of Biomedical Data Science, 1265 Welch Road, Stanford, CA, 94305, USA.
Kathleen HornbackerStanford University School of Medicine, Stanford Cancer Institute, Department of Medicine, Division of Oncology, 875 Blake Wilbur, Stanford, CA, 94305, USA.
Jalen A BensonStanford University School of Medicine, Department of Cardiothoracic Surgery, 300 Pasteur Drive, Falk Cardiovascular Research Building, Stanford, CA, 94305, USA.
Gerald J BerryStanford University School of Medicine, Department of Pathology, 300 Pasteur Drive, Stanford, CA, 94304, USA.
Natalie S LuiStanford University School of Medicine, Department of Cardiothoracic Surgery, 300 Pasteur Drive, Falk Cardiovascular Research Building, Stanford, CA, 94305, USA.
Pamela L KunzStanford University School of Medicine, Stanford Cancer Institute, Department of Medicine, Division of Oncology, 875 Blake Wilbur, Stanford, CA, 94305, USA; Yale School of Medicine, Gastrointestinal Cancers Program, 6 Devine Street, North Haven, CT, 06473, USA.
Sukhmani K PaddaStanford University School of Medicine, Stanford Cancer Institute, Department of Medicine, Division of Oncology, 875 Blake Wilbur, Stanford, CA, 94305, USA. Electronic address: padda@stanford.edu.
Stanford University · USKaiser Permanente Richmond Medical Center · USMassachusetts General Hospital · USStanford Cancer InstituteStanford Medicine · USYale Cancer Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR003142NCI NIH HHS P30 CA124435NCRR NIH HHS UL1 RR025744
6 · The paper itself

Abstract

backgroundWell-differentiated lung neuroendocrine tumors (NETs), also known as typical and atypical carcinoids, have a decreased incidence of lymph node (LN) and distant metastases compared to poorly differentiated lung NETs. We aimed to (i) examine the clinicopathologic features associated with LN involvement in lung carcinoids and (ii) describe the postoperative management of patients with LN metastases.

methodsWe identified 98 patients who underwent surgical resection and lymph node sampling at Stanford University. We assessed the following and used AJCC staging version 7: clinical features (age, sex, race, prior malignancy, smoking history), tumor features (functional syndrome, histology, size, location, laterality), pre-operative workup performed (imaging and suspicion of LN metastases), surgery (nodes and stations sampled, margin status, surgical approach, and type of surgery), and recurrence outcome. These features were examined between patients with and without LN metastases using the Wilcoxon test (continuous variables) and Fisher's exact test (categorical variables).

results87 patients (89%) had typical carcinoid and 11 patients (11%) had atypical carcinoid. 17 patients were found to have at least one positive lymph node, with 11 having N1 disease and 6 having N2 disease. In the univariable analysis, patients with lymph node disease were more likely to have recurrence of lung carcinoid (29% vs. 6%, p=0.01). In the multivariable logistic regression, there was a trend towards performance of preoperative SSTR imaging and lymph node involvement (OR = 3.06, p=0.07). No patients received adjuvant therapy.

conclusionWe found a trend for the performance of SSTR imaging and association of lymph node metastases in both univariable and multivariable analysis. A large proportion (41%) of patients with lymph node positive disease had < 2 cm tumors. This suggests the potential importance of incorporating SSTR imaging into routine practice and not restricting the use of this staging modality in patients with small tumors.

Indexed as

Carcinoid TumorLung NeoplasmsHumansLungLymphatic MetastasisLymph NodesNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRetrospective StudiesLung cancerLung carcinoidsLymph node metastasesNeuroendocrine tumorsSomatostatin-receptor (SSTR) imaging

Identifiers

PMID33551175
PMCPMC8026717
OpenAlexW3122317426

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.