Evidence map›Paper›PMID 33550933›Full record

ArticleTechnology in cancer research & treatment

MicroRNA-936 Targets JAG1 and Inhibits the Proliferation of Hepatocellular Carcinoma Cells.

Junmei Tian, Yongfei Zhao, Li Li, Yanling Cui, Yang Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Junmei TianNutritional Department, Luoyang Central Hospital Affiliated Zhengzhou University, Luoyang, Henan, People's Republic of China.
Yongfei ZhaoNutritional Department, Luoyang Central Hospital Affiliated Zhengzhou University, Luoyang, Henan, People's Republic of China.
Li LiNutritional Department, Luoyang Central Hospital Affiliated Zhengzhou University, Luoyang, Henan, People's Republic of China.
Yanling CuiNutritional Department, Kaifeng Central Hospital, Kaifeng, Henan, People's Republic of China.
Yang WuOncology Department, Luoyang Central Hospital Affiliated Zhengzhou University, Luoyang, Henan, People's Republic of China.ORCID 0000-0002-7289-9831
Luoyang Central Hospital Affiliated to Zhengzhou University · CNKaifeng University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Investigating the underlying molecular mechanism is essential for the treatment and prognosis of HCC. Emerging evidence suggests that microRNAs (miRNAs) play pivotal roles in cancer progression. Down-regulation of miR-936 has been found in several cancers, which serves as a tumor suppressor to inhibit the development of cancers. However, the clinical significance and functional roles of miR-936 in HCC have not been determined. To explore this, the expression of miR-936 in HCC tissues and cells was detected by RT-qPCR. Cell Counting Kit-8 (CCK-8) assay, cell migration and cell cycle analysis were performed to evaluate the effects of miR-936 on the growth of HCC cells. The targets of miR-936 were predicted using the miRDB database and confirmed by luciferase reporter experiments. The protein expression of targets was determined by western blot. The results showed that miR-936 was significantly decreased in HCC tissues and cell lines. Low expression of miR-936 was associated with the advance progression and poor survival of HCC patients (P = 0.0036). Functional study revealed that overexpression of miR-936 inhibited the proliferation, migration (decreased to ∼0.26 fold) and induced cell cycle arrested in G

Indexed as

Gene Expression Regulation, NeoplasticRNA Interference3' Untranslated RegionsCarcinoma, HepatocellularCell CycleCell Line, TumorCell MovementCell ProliferationHumansJagged-1 ProteinLiver NeoplasmsMicroRNAsPrognosis3' Untranslated RegionsJAG1 protein, humanJagged-1 ProteinMicroRNAsMIRN936 microRNA, humancell proliferationhepatocellular carcinomaJAG1miR-936

Identifiers

PMID33550933
PMCPMC7876578
OpenAlexW3127641120

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.