Evidence map›Paper›PMID 33550919›Full record

ArticleEpigenetics2022

Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors.

R C Huang, P E Melton, M A Burton, L J Beilin, R Clarke-Harris, E Cook, K M Godfrey, G C Burdge, T A Mori, D Anderson and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Epigenetics of Childhood Obesity.Hormone research in paediatrics · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Epigenetics in Precision Nutrition.Journal of personalized medicine · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 3 countries.

R C HuangTelethon Kids Institute, University of Western Australia, Australia.ORCID 0000-0002-8464-6639
P E MeltonCurtin/UWA Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, The University of Western Australia, Perth, Australia.ORCID 0000-0003-4026-2964
M A BurtonSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
L J BeilinMedical School, The University of Western Australia, Australia.
R Clarke-HarrisSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0002-6888-9518
E CookSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
K M GodfreySchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0002-4643-0618
G C BurdgeSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
T A MoriMedical School, The University of Western Australia, Australia.
D AndersonTelethon Kids Institute, University of Western Australia, Australia.ORCID 0000-0003-0643-4136
S RauschertTelethon Kids Institute, University of Western Australia, Australia.
J M CraigCentre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0003-3979-7849
M S KoborDepartment of Medical Genetics, University of British Columbia, Vancouver Canada.
J L MacIsaacDepartment of Medical Genetics, University of British Columbia, Vancouver Canada.
A M MorinDepartment of Medical Genetics, University of British Columbia, Vancouver Canada.
W H OddyMenzies Institute for Medical Research, University of Tasmania, Australia.ORCID 0000-0002-6119-7017
C E PennellSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Australia.ORCID 0000-0002-0937-6165
J D HolbrookCurtin/UWA Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, The University of Western Australia, Perth, Australia.ORCID 0000-0003-1791-6894
K A LillycropCurtin/UWA Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, The University of Western Australia, Perth, Australia.ORCID 0000-0001-7350-5489
University of Southampton · GBThe University of Western Australia · AUThe Kids Research Institute Australia · AUUniversity of British Columbia · CAUniversity of Tasmania · AURoyal Children's Hospital · AUUniversity of Newcastle Australia · AU

Funding

British Heart Foundation RG/15/17/3174British Heart Foundation RG/15/17/31749Department of HealthMedical Research Council G0400491Medical Research Council MC_PC_21000Medical Research Council MC_PC_21001Medical Research Council MC_PC_21003Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/4
6 · The paper itself

Abstract

Epigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs (Bonferroni corrected p < 1.06E-07) associated with body mass index (BMI), 10 with waist circumference (WC) and 9 with subcutaneous fat thickness. DmCpGs within Ras Association (RalGDS/AF-6), Pleckstrin Homology Domains 1 (

Indexed as

AdiposityLeptinAdolescentBody Mass IndexDicarboxylic Acid TransportersDNADNA MethylationFemaleHumansObesityPregnancyRNA-Binding ProteinsYoung AdultDicarboxylic Acid TransportersDNALEP protein, humanLeptinMSI2 protein, humanRNA-Binding ProteinsSlc25a10 protein, humanadiposityadolescencebody Compositionbody mass indexDNA methylationepigenetic Variationhigh-sensitivity C-reactive Proteininflammationleptinmaternalthe Raine Studyyouth

Identifiers

PMID33550919
PMCPMC9423832
OpenAlexW3128506218

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.