Evidence map›Paper›PMID 33550882›Full record

ArticleGut microbes

Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family.

Jingjing Du, Peiwen Zhang, Jiang Luo, Linyuan Shen, Shunhua Zhang, Hao Gu, Jin He, Linghui Wang, Xue Zhao, Mailing Gan and 18 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 2 syntheses or guidelines pooled it, 146 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Host-Microbiota Interactions in Obesity: Immune Metabolic Dysregulation.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
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  12. Article
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  16. Article
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  19. miR-6402 targetsAdipocyte · 2025
    Article
  20. Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 2 institutions in 1 country.

Jingjing DuCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Peiwen ZhangCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Jiang LuoCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.ORCID 0000-0002-2087-6873
Linyuan ShenCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Shunhua ZhangCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Hao GuCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Jin HeCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Linghui WangCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Xue ZhaoCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Mailing GanCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Liu YangCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Lili NiuCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Ye ZhaoCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Qianzi TangCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Guoqing TangCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Dongmei JiangCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Yanzhi JiangCollege of Life and Biology Science, Sichuan Agricultural University , Chengdu, China.
Mingzhou LiCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Anan JiangCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Long JinCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Jideng MaCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Surong ShuaiCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Lin BaiCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Jinyong WangChongqing Academy of Animal Science , Rongchang, China.
Bo ZengCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
De WuInstitute of Animal Nutrition, Sichuan Agricultural University , Chengdu, China.
Xuewei LiCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Li ZhuCollege of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China.
Sichuan Agricultural University · CNChongqing Academy of Animal Science · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Betaine is a natural compound present in commonly consumed foods and may have a potential role in the regulation of glucose and lipids metabolism. However, the underlying molecular mechanism of its action remains largely unknown. Here, we show that supplementation with betaine contributes to improved high-fat diet (HFD)-induced gut microbiota dysbiosis and increases anti-obesity strains such as

Indexed as

AnimalsAnti-Obesity AgentsBacteriaBetaineDietary SupplementsDiet, High-FatFatty Acids, VolatileFemaleGastrointestinal MicrobiomeMetabolic SyndromeMiceMicroRNAsObesityYY1 Transcription FactorAnti-Obesity AgentsBetaineFatty Acids, VolatileMicroRNAsMIRN378 microRNA, mouseYy1 protein, mouseYY1 Transcription FactorBetainegut microbiotamicroRNAobesitySCFA

Identifiers

PMID33550882
PMCPMC7889173
OpenAlexW3127170945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.