ArticleJournal of animal physiology and animal nutrition2021
The effect of urine acidification on calcium oxalate relative supersaturation in cats.
Article in Journal of animal physiology and animal nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Feline Comorbidities: A nutritional approach to management.Journal of feline medicine and surgery · 2025Review
- Metabolomic Changes Associated with AGXT2 Genotype Variants and Stone Formation in a Colony of Cats.Genes · 2024Article
- Starch to protein ratio and food moisture content influence water balance and urine supersaturation in cats.PloS one · 2024Article
- Retrospective analysis of 131 feline uroliths from the Republic of Ireland and Northern Ireland (2010-2020).Irish veterinary journal · 2023Article
- Relative supersaturation values distinguish between feline urinary and non-urinary foods and align with expected urine analytes contributions to uroliths.Frontiers in veterinary science · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
There is an apparent reciprocal relationship between magnesium ammonium phosphate (MAP, struvite) and calcium oxalate (CaOx) urolithiasis incidence rate in cats. The number of struvite uroliths submitted for analysis over the past 35 years has been decreasing, with an increase in CaOx urolith submissions. Commercial diets aimed to dissolve struvite uroliths are typically acidified, and it has been suggested that dietary acidification increases urinary calcium excretion and the risk of CaOx crystallization. The objective of this study was to assess the effect of urine acidification on the relative supersaturation (RSS) of CaOx in cats, as a representation of crystallization risk. Four diets were extruded to contain identical nutrient contents, but with gradual acidification (0, 0.6, 1.3 and 1.9% sodium bisulphate substituted sodium chloride in diets A, B, C and D respectively). Thirteen adult cats were fed each diet sequentially for a minimum of 10 days. Average urine pH was 6.4, 6.2, 6.0 and 5.9 on diets A, B, C and D respectively (p < 0.0001). Struvite RSS decreased on diets inducing more acidic urine pH (p < 0.0001). Urinary calcium excretion and concentration increased with diets inducing lower urine pH (p < 0.0001), but oxalate excretion and concentration decreased (p < 0.001). CaOx RSS was not different between diets (p = 0.63). These results suggest that a lower diet base excess and resulting urine pH to support struvite dissolution do not increase the risk for CaOx crystallization in the range of urine pH representative of most commercial feline diets. Long-term studies are needed to confirm this.
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