Evidence map›Paper›PMID 33550519›Full record

ArticleAIDS and behavior2021

Reduced Working Memory is Associated with Heavier Alcohol Consumption History, Role Impairment and Executive Function Difficulties.

Vaughn E Bryant, Mark K Britton, Joseph M Gullett, Eric C Porges, Adam J Woods, Robert L Cook, John Williamson, Nicole Ennis, Kendall J Bryant, Carolyn Bradley and 1 more

Open access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Vaughn E BryantDepartment of Epidemiology, University of Florida, Emerging Pathogens Institute, 2055 Mowry Road, P.O. Box 100009, Gainesville, FL, 32610, USA. vebryant@phhp.ufl.edu.ORCID http://orcid.org/0000-0002-9269-7612
Mark K BrittonDepartment of Clinical and Health Psychology, University of Florida, Center for Cognitive Aging and Memory, Cognitive Aging and Memory Clinical Translational Research Program, 1225 Center Drive, Gainesville, FL, 32607, USA.
Joseph M GullettDepartment of Clinical and Health Psychology, University of Florida, Center for Cognitive Aging and Memory, Cognitive Aging and Memory Clinical Translational Research Program, 1225 Center Drive, Gainesville, FL, 32607, USA.
Eric C PorgesDepartment of Clinical and Health Psychology, University of Florida, Center for Cognitive Aging and Memory, Cognitive Aging and Memory Clinical Translational Research Program, 1225 Center Drive, Gainesville, FL, 32607, USA.
Adam J WoodsDepartment of Clinical and Health Psychology, University of Florida, Center for Cognitive Aging and Memory, Cognitive Aging and Memory Clinical Translational Research Program, 1225 Center Drive, Gainesville, FL, 32607, USA.
Robert L CookDepartment of Epidemiology, University of Florida, Emerging Pathogens Institute, 2055 Mowry Road, P.O. Box 100009, Gainesville, FL, 32610, USA.
John WilliamsonDepartment of Clinical and Health Psychology, University of Florida, Center for Cognitive Aging and Memory, Cognitive Aging and Memory Clinical Translational Research Program, 1225 Center Drive, Gainesville, FL, 32607, USA.
Nicole EnnisDepartment of Behavioral Sciences and Social Medicine, Florida State University, 2010 Levy Ave, Suite 254, Tallahassee, FL, 32310, USA.
Kendall J BryantNational Institute of Alcohol Abuse and Alcoholism, 6700B Rockledge Drive, Bethesda, MD, 20892-6902, USA.
Carolyn BradleyDepartment of Epidemiology, University of Florida, Emerging Pathogens Institute, 2055 Mowry Road, P.O. Box 100009, Gainesville, FL, 32610, USA.
Ronald A CohenDepartment of Clinical and Health Psychology, University of Florida, Center for Cognitive Aging and Memory, Cognitive Aging and Memory Clinical Translational Research Program, 1225 Center Drive, Gainesville, FL, 32607, USA.
University of Florida · USFlorida State University · USNational Institute on Alcohol Abuse and Alcoholism · US

Funding

Virology CoreP01AA019072 · NIAAA · BROWN UNIVERSITY · PI KAHLER, CHRISTOPHER W. · 2010 to 2024
$19.7M
Pharmacotherapy for alcohol consumptionin HIV-infected women: randomized trialU01AA020797 · NIAAA · UNIVERSITY OF FLORIDA · PI COHEN, RONALD A, COOK, ROBERT L · 2011 to 2021
$7.2M
Translational Science Training to Reduce the Impact of Alcohol on HIV InfectionT32AA025877 · NIAAA · UNIVERSITY OF FLORIDA · PI Robert L Cook, DEBRA E LYON · 2018 to 2026
$3.3M
Age Effects on HIV-associated Brain DysfunctionR01MH074368 · NIMH · MIRIAM HOSPITAL · PI COHEN, RONALD A · 2006 to 2010
$1.7M
Cognitive and functional deficits associated with reduced cortical GABA in HIV-infected heavy drinkersK01AA025306 · NIAAA · UNIVERSITY OF FLORIDA · PI PORGES, ERIC · 2017 to 2021
$801k
Feasibility of SBIRT for Underserved HIV+ Adults 50+ in Primary Care SettingsK23DA039769 · NIDA · UNIVERSITY OF FLORIDA · PI ENNIS, NICOLE · 2016 to 2020
$769k
Working memory: a critical factor underlying alcohol reduction intervention responseF31AA024060 · NIAAA · UNIVERSITY OF FLORIDA · PI BRYANT, VAUGHN E · 2015 to 2017
$115k
NIAAA NIH HHS F31 AA024060NIAAA NIH HHS K01 AA025306NIAAA NIH HHS P01 AA019072NIAAA NIH HHS P01 AA19072NIAAA NIH HHS T32 AA025877NIAAA NIH HHS U01 AA020797NIDA NIH HHS K23 DA039769NIMH NIH HHS R01 MH074368
6 · The paper itself

Abstract

Both HIV status and heavy alcohol use have been associated with reduced cognitive function, particularly in the domains of working memory and executive function. It is unclear what aspects of working memory and executive function are associated with HIV status and heavy alcohol use and whether performance on these measures are associated with functional impairment. We examined the relationship between HIV, history of heavy alcohol consumption, and HIV/alcohol interaction on speeded tests of frontal inhibitory abilities, a working memory task related to mental manipulation of letters and numbers, cognitive flexibility, and measures of functional impairment. Study participants included 284 individuals (151 HIV +) recruited from two different studies focusing on HIV associated brain dysfunction, one specific to the effects of alcohol, the other specific to the effects of aging. HIV status was not independently associated with working memory and executive function measures. Higher level of alcohol consumption was associated with reduced performance on Letter Number Sequencing. Poorer Letter Number Sequencing performance was associated with role impairment (an inability to do certain kinds of work, housework, or schoolwork) and executive function difficulties. Future studies should examine causal associations and interventions targeting working memory abilities.

Indexed as

Executive FunctionHIV InfectionsAlcohol DrinkingHumansMemory, Short-TermNeuropsychological TestsAlcoholExecutiveFunctionHIVImpairmentMemoryRoleWorking

Identifiers

PMID33550519
PMCPMC8935631
OpenAlexW3129096593

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.