Evidence map›Paper›PMID 33550454›Full record

ArticlePediatric surgery international2021

Thoracoscopic oesophageal atresia/tracheo-oesophageal fistula (OA/TOF) repair is associated with a higher stricture rate: a single institution's experience.

H Thakkar, D M Mullassery, S Giuliani, S Blackburn, K Cross, J Curry, Paolo De Coppi

Open access · hybridAbstract read
In one paragraph

Article in Pediatric surgery international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

H ThakkarDepartment of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital, London, UK.
D M MullasseryDepartment of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital, London, UK.
S GiulianiDepartment of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital, London, UK.
S BlackburnDepartment of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital, London, UK.
K CrossDepartment of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital, London, UK.
J CurryDepartment of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital, London, UK.
Paolo De CoppiDepartment of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital, London, UK. p.decoppi@ucl.ac.uk.
University College London · GBGreat Ormond Street Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThoracoscopic OA/TOF repair was first described in 1999. Currently, less than 10% of surgeons routinely employ minimally access surgery. Our primary aim was to review our immediate-, early- and long-term outcomes with this technique compared with the open approach.

methodsA retrospective review of all patients undergoing primary OA/TOF (Type C) repair at our institution from 2009 was conducted. Outcome measures included length of surgery, conversion rate from thoracoscopy, early complications such as anastomotic leak and post-operative complications such as anastomotic strictures needing dilatations. Fisher's exact and Kruskal-Wallis tests were used for statistical analysis.

results95 patients in total underwent OA/TOF repair during the study period of which 61 (64%) were completed via an open approach. 34 were attempted thoracoscopically of which 11 (33%) were converted. There was only one clinically significant anastomotic leak in our series that took place in the thoracoscopic group. We identified a significantly higher stricture rate in our thoracoscopic cohort (72%) versus open surgery (43%, P < 0.05). However, the median number of dilations (3) performed was not significantly different between the groups. There was one recurrent fistula in the thoracoscopic converted to open group. Our median follow-up was 60 months across the groups.

conclusionIn our experience, the clinically significant leak rate for both open and thoracoscopic repair as well as recurrent fistula is much lower than has been reported in the literature. We do not routinely perform contrast studies and are, thus, reporting clinically significant leaks only. The use of post-operative neck flexion, ventilation and paralysis is likely to be protective towards a leak. Thoracoscopic OA/TOF repair is associated with a higher stricture rate compared with open surgery; however, these strictures respond to a similar number of dilatations and are no more refractory. Larger, multicentre studies may be useful to investigate these finding further.

Indexed as

Anastomotic LeakCohort StudiesConstriction, PathologicDilatationEsophageal AtresiaFemaleHumansInfant, NewbornMalePostoperative ComplicationsRetrospective StudiesThoracoscopyTracheoesophageal FistulaMinimal access surgeryOesophageal atresiaStrictureThoracoscopic

Identifiers

PMID33550454
PMCPMC7900027
OpenAlexW3127405034

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.