Evidence map›Paper›PMID 33550427›Full record

ArticleHeart and vessels2021

Influence of different physiological hemodynamics on fractional flow reserve values in the left coronary artery and right coronary artery.

Kensaku Wada, Kenichi Fujii, Keita Horitani, Hiroshi Kishimoto, Kenta Hashimoto, Hiroki Shibutani, Satoshi Tsujimoto, Koichiro Matsumura, Munemitsu Otagaki, Shun Morishita and 2 more

Abstract read
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Article in Heart and vessels, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A Vessel-Specific Analysis of Deferred Lesions Using the Instantaneous Wave-Free Ratio and Fractional Flow Reserve.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kensaku WadaDivision of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, 5731010, Japan.
Kenichi FujiiDivision of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, 5731010, Japan. fujiik@hirakata.kmu.ac.jp.ORCID http://orcid.org/0000-0001-7721-2990
Keita HoritaniDivision of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, 5731010, Japan.
Hiroshi KishimotoDivision of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, 5731010, Japan.
Kenta HashimotoDivision of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, 5731010, Japan.
Hiroki ShibutaniDivision of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, 5731010, Japan.
Satoshi TsujimotoDivision of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, 5731010, Japan.
Koichiro MatsumuraDepartment of Cardiology, Kansai Medical University Medical Center, Moriguchi, Japan.
Munemitsu OtagakiDepartment of Cardiology, Kansai Medical University Medical Center, Moriguchi, Japan.
Shun MorishitaDivision of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, 5731010, Japan.
Masayoshi IwasakiDivision of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, 5731010, Japan.
Ichiro ShiojimaDivision of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, 5731010, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough the left coronary artery (LCA) has a flow profile in that most blood flow occurs during diastole rather than systole, the right coronary artery (RCA) has a flow pattern that is less diastolic dominant. This study assessed whether coronary pressure waveforms distal to stenoses with the same fractional flow reserve (FFR) was the same between the LCA and RCA.

methodsA total of 347 vessels from 318 patients who underwent FFR measurements were included. Conventional FFR was calculated as the ratio of the mean coronary distal pressure (Pd) to the mean aortic pressure (Pa) at maximal hyperemia. The pressure drop ratios in systole (PDR

resultsAnalysis of covariance of the regression line of correlation between conventional FFR and PDR

conclusionsThe pressure waveform distal to the stenosis differs between the LCA and RCA. In the LCA, the decrease in diastolic pressure mainly contributed to the drop in FFR, whereas in the RCA, it was the decrease in systolic pressure.

Indexed as

Coronary StenosisFractional Flow Reserve, MyocardialHyperemiaCoronary VesselsHemodynamicsHumansCoronary artery diseaseCoronary physiologyFractional flow reserve

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.