Evidence map›Paper›PMID 33550254›Full record

ArticleBMJ open2021

Feasibility and acceptability of a multi-domain intervention to increase Mediterranean diet adherence and physical activity in older UK adults at risk of dementia: protocol for the MedEx-UK randomised controlled trial.

Oliver M Shannon, Vivian Lee, Rafe Bundy, Rachel Gillings, Amy Jennings, Blossom Stephan, Michael Hornberger, George Balanos, Stella Maria Paddick, Sarah Hanson and 7 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03673722 (A Randomised Controlled Trial Investigating the Feasibility of a Multi-domain Intervention to Increase Mediterranean Diet), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03673722 nacompletednot on this map

A Randomised Controlled Trial Investigating the Feasibility of a Multi-domain Intervention to Increase Mediterranean Diet (MedDiet) Score and Physical Activity (PA) of Older UK Adults Who Are at Above Average Risk of Dementia

TypeinterventionalSponsorUniversity of East AngliaRan2019 to 2023Enrolled108ConditionsDementiaArmsFoods consistent with a MDP, Physical Activity, Control
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Oliver M ShannonHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0001-8208-6837
Vivian LeeSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Rafe BundyDepartment of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK.
Rachel GillingsDepartment of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK.
Amy JenningsDepartment of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK.
Blossom StephanInstitute of Mental Health, Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, Nottinghamshire, UK.
Michael HornbergerNorwich Medical School, University of East Anglia, Norwich, UK.
George BalanosSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Stella Maria PaddickInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK.
Sarah HansonSchool of Health Sciences, Norwich Medical School, University of East Anglia, Norwich, UK.
Wendy HardemanBehavioural and Implementation Science Group, School of Health Sciences, University of East Anglia, Norwich, UK.
Rebecca HolmesDepartment of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK.
Nikki GarnerDepartment of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK.
Sarah AldredSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Mario SiervoSchool of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, UK.
John C MathersHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Anne Marie MinihaneDepartment of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK a.minihane@uea.ac.uk.
University of East Anglia · GBUniversity of Birmingham · GBNewcastle University · GBUniversity of Nottingham · GBNorth Tyneside General Hospital · GB

Funding

Medical Research Council MR/P020941/1
6 · The paper itself

Abstract

introductionDementia prevalence continues to increase, and effective interventions are needed to prevent, delay or slow its progression. Higher adherence to the Mediterranean diet (MedDiet) and increased physical activity (PA) have been proposed as strategies to facilitate healthy brain ageing and reduce dementia risk. However, to date, there have been no dementia prevention trials in the UK focussed on combined dietary and PA interventions. This study aims to: (1) assess feasibility and acceptability of a theory-underpinned digital and group-based intervention for dementia risk reduction in an 'at risk' UK cohort; (2) evaluate behaviour change responses to the intervention; and, (3) provide information on cognitive, neurological, vascular and physiological outcomes to inform the design of a follow-on, full-scale efficacy trial.

methodsOne hundred and eight participants aged 55 to 74 years with a QRISK2 score of ≥10% will be recruited to take part in this 24-week multi-site study. Participants will be randomised into three parallel arms: (1) Control; (2) MedDiet; and, (3) MedDiet+PA. The study will evaluate a personalised website, group session and food delivery intervention to increase MedDiet adherence and PA in older adults at risk of dementia. Diet and PA will be monitored prior to, during and following the intervention. Feasibility, acceptability and hypothesised mediators will be assessed in addition to measures of cognitive function, brain structure/perfusion (MRI), vascular function and metabolic markers (blood, urine and faecal) prior to, and following, the intervention. DISCUSSION: This trial will provide insights into the feasibility, acceptability and mechanism of effect of a multi-domain intervention focussed on the MedDiet alone and PA for dementia risk reduction in an 'at risk' UK cohort. ETHICS AND DISSEMINATION: The study has received NHS REC and HRA approval (18/NI/0191). Findings will be disseminated via conference presentations, public lectures, and peer-reviewed publications. TRIAL REGISTRATION DETAILS: ClinicalTrials.gov NCT03673722.

Indexed as

DementiaDiet, MediterraneanAgedExerciseFeasibility StudiesHumansMiddle AgedRandomized Controlled Trials as TopicUnited Kingdomdementianutrition & dieteticspublic health

Identifiers

PMID33550254
PMCPMC7925921
OpenAlexW3127638540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.